When will I ovulate after taking letrozole?
Letrozole is taken to stimulant ovulation in women who are having difficulty conceiving. If the course of letrozole is successful (results in ovulation), then ovulation should occur along the normal time course of your menstrual cycle: approximately 12 to 16 days after the first day of your menstrual bleeding.
There are ways to monitor for ovulation to determine when the best chance is to conceive.
Infertility is the inability to get pregnant after 1 year of having sexual intercourse on a consistent basis without the use of birth control. The most common cause of female infertility is problems with ovulation.
Letrozole is used to stimulate ovulation. It does this by affecting certain female hormone levels. Once successful ovulation is achieved, the egg may be fertilized through timed sexual intercourse, intrauterine insemination or in vitro fertilization.
The normal menstrual cycle consists of three phases. The second phase is called the ovulatory phase. It occurs anywhere between 12 and 16 days after the first day of menstrual bleeding. When you take letrozole to stimulate ovulation, it supports this normal timeframe of ovulation if it works.
There are several ways to monitor ovulation:
- Blood samples may be taken to measure hormone levels.
- An ultrasound of the ovaries may be performed to look at the follicles where a woman's eggs reside and mature.
- Your body temperature rises just after ovulation, so body temperature may be tracked.
- There are also home ovulation-predictor kits that measure the levels of a hormone called luteinizing hormone in your urine.
In a study that looked at the use of letrozole for stimulating ovulation, women with polycystic ovary syndrome were permitted to take up to 5 courses of letrozole in an attempt to conceive. In the study:
- About 62% of all letrozole treatment cycles resulted in ovulation
- About 89% of the women taking letrozole successfully ovulated
- About 41% of the women conceived
Related questions
References
- American Society for Reproductive Medicine (ASRM). Medicines for Inducing Ovulation. 2016. Available at: https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/medications-for-inducing-ovulation-booklet/. [Accessed July 19, 2021].
- American College of Obstetricians and Gynecologists (ACOG). Fertility FAQs. October 2019. Available at: https://www.acog.org/womens-health/faqs/treating-infertility. [Accessed July 19, 2021].
- Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014;371(2):119-129. https://doi.org/10.1056/nejmoa1313517.
Read next
Is letrozole a form of chemotherapy?
Letrozole is not chemotherapy, it is a type of hormone therapy that is used to treat people with breast cancer that is hormone receptor-positive. If your cancer is hormone receptor-negative, then letrozole will not be of any benefit. Traditional chemotherapy agents stop cancer cells from growing, dividing, and making more cells. Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. Estrogen is a hormone that causes estrogen receptor-positive (ER+) breast cancer to grow. Letrozole belongs to the class of medicines known as aromatase inhibitors. Continue reading
Does letrozole affect blood sugar levels?
Although diabetes and blood sugar increases are not listed as a side effect of letrozole treatment, treatment with letrozole is associated with a significantly increased risk for high blood sugar levels and diabetes. An Israeli study that investigated 2,246 breast cancer survivors found that women treated with letrozole were 4.3 times more likely to develop diabetes than women not taking letrozole, although the number of women prescribed letrozole was small. Overall, women prescribed any sort of hormone treatment (either tamoxifen or an aromatase inhibitor such as letrozole) had a 2.5 times higher risk of diabetes. Continue reading
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