Can I take omeprazole in the morning and famotidine at night?
Yes, you could take omeprazole in the morning and famotidine at night but there are not many studies investigating this approach. Preliminary results suggest that taking your medication this way may provide superior control of gastric acid secretion at night without compromising the effectiveness of omeprazole in the morning. More research is needed.
One small study that looked at the combination of famotidine and omeprazole as a single pill reported a shortening of the time to reach a more favorable gut ph of >4 and a longer duration of effect. Another study that used Pepcid Complete (a combination formulation that contains famotidine and 2 antacids, calcium carbonate and magnesium hydroxide) reported that omeprazole in the morning and Pepcid Complete at night were superior than omeprazole morning and night.
References
- Fändriks L, Lönroth H, Pettersson A, Vakil N. Can famotidine and omeprazole be combined on a once-daily basis? Scand J Gastroenterol. 2007 Jun;42(6):689-94. doi: 10.1080/00365520601026665. PMID: 17505990.
- New Study Finds Nocturnal Acid Breakthrough Better Controlled With OTC Combination Heartburn Product Than Second Dose of Prescription PPI https://johnsonandjohnson.gcs-web.com/static-files/011fbc97-b98b-4a0d-aed9-af689a4fbf64
Read next
Related medical questions
- What foods should I avoid when taking omeprazole?
- Is omeprazole (Prilosec) bad for your kidneys?
- Does omeprazole cause cancer?
- How soon after taking levothyroxine can I take omeprazole?
- When's the best time to take omeprazole: before or after a meal?
- Nexium vs Prilosec: What's the difference between them?
- Over the Counter Medication for Pets
- What are the risks associated with heartburn medications?
- Can you take famotidine long term?
Drug information
Related support groups
- Omeprazole (121 questions, 251 members)
- Famotidine (25 questions, 35 members)