What is the difference between HIV treatments Odefsey and Complera?
Odefsey and Complera are both three-drug antiviral combinations containing emtricitabine, rilpivirine and tenofovir for the treatment of HIV-1 infection. The difference between Odefsey and Complera is in the form of tenofovir contained in each product.
Odefsey contains a newer form of tenofovir called tenofovir alafenamide (TAF) and Complera contains the original form of tenofovir as tenofovir disoproxil fumarate (TDF).
Tenofovir alafenamide is a prodrug of tenofovir and is inactive when it is first taken. After it enters the body, it is changed to its active form in the HIV-infected cell much more efficiently than TDF, which results in much lower levels of drug in the blood, but higher levels within the cells where HIV-1 replicates. Therefore, TAF can be given at roughly one-tenth the dose of TDF. Due to smaller doses and lower levels of tenofovir in the blood, kidney toxicity and decreased bone mineral density may be less of a concern with TAF, as noted by laboratory values in studies.
| Odefsey | Complera | |
|---|---|---|
| FDA Approved | March 1, 2016 | August 10, 2011 |
| How Supplied |
Each tablet contains:
|
Each tablet contains:
|
| Indication |
HIV-1 Infection
|
HIV-1 Infection
|
Odefsey and Complera are both manufactured by Gilead Sciences Inc.
Related questions
Read next
Does Biktarvy increase cholesterol?
Biktarvy (bictegravir, emtricitabine and tenofovir alafenamide) can increase cholesterol levels due to the tenofovir alafenamide (TAF) component, but this does not appear to be a frequent or significant side effect. Continue reading
Which medicines should not be taken with Biktarvy?
- Biktarvy is a complete regimen and use with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
- Biktarvy is associated with many drug interactions as it contains three different medicines, increasing your risk for interactions. Have your health care provider check for possible interactions with other prescription medicines, OTCs or herbal you take.
- You should not take Biktarvy with dofetilide (Tikosyn), a drug used for heart rhythm disorders or rifampin (Rifadin), a medicine for tuberculosis (TB). These drugs are contraindicated with the use of Biktarvy.
Who are the actors in the Dovato commercial?
Three real-life patients feature in the Dovato commercial “Detect This” released on May 23, 2022. They are Jovon [surname withheld], Ann Edwards, and Armando [surname withheld]. Continue reading
Related medical questions
- How much does HIV treatment Cimduo cost?
- What drugs are contained in the HIV treatment Delstrigo?
- What drugs are contained in the HIV treatment Cimduo?
- What drugs are contained in the HIV treatment Symfi Lo?
- What drugs are contained in the HIV treatment Symtuza?
- What drugs are contained in HIV treatment Juluca?
- How do you increase your CD4 count?
- What is an undetectable HIV viral load?
- Can Descovy be used for pre-exposure prophylaxis (PrEP) in HIV?
- Modafinil (Provigil) vs Adderall: What's the difference?
- What if I miss a dose of Biktarvy?
- Who are the actors in the Biktarvy commercials?
- How fast or how long does it take Biktarvy to work?
- Does Dovato cause weight gain?
- Is Biktarvy covered by insurance?
- Can I drink alcohol while taking Biktarvy?
- What do I need to know about Drug Interactions?
- How effective is Dovato for HIV?
- Apretude vs Descovy: How do they compare?
- What is the recreational use of ART, including Truvada?
- What is Biktarvy used for?
- What are 9 key Dovato side effects to watch out for?
- Does Biktarvy cause hair loss?
- Apretude vs Cabenuva, what is the difference?
- What is the generic name for Biktarvy?
- Can you crush Biktarvy tablets?
- What is the difference between Biktarvy and Descovy?
- Who are the actors in the Descovy commercial?
- What is the difference between Vemlidy and Viread?
- Can Leronlimab (PRO 140) be used to treat COVID-19 (coronavirus)?
Related support groups
- Tenofovir (8 questions, 14 members)
- Tenofovir Alafenamide (6 questions, 3 members)
- Emtricitabine (4 questions, 5 members)
- Rilpivirine (2 questions, 3 members)
- Emtricitabine/rilpivirine/tenofovir Alafenamide (1 questions, 3 members)
- Odefsey (1 questions, 3 members)
- Emtricitabine/rilpivirine/tenofovir (1 questions, 3 members)
- Complera (1 questions, 19 members)
- HIV Infection (90 questions, 246 members)
