What is Nplate used for and how does it work?

Nplate (romiplostim) is an FDA-approved biologic medication used to:

• Treat adults with immune thrombocytopenia (ITP) when corticosteroids, immunoglobulins or surgery to remove the spleen (splenectomy) has not worked well enough
• Treat children 1 year of age and older with ITP for at least 6 months when corticosteroids, immunoglobulins or surgery to remove the spleen has not worked well enough
• Increase survival in people (including adults and children as young as full term neonates) with Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS), which occurs following acute exposure to doses of radiation that reduce the activity of the bone marrow (myelosuppressive) resulting in fewer platelets and other cells

How does Nplate work?

Nplate boosts platelet production by acting as a thrombopoietin (TPO) receptor agonist. Unlike some other treatments, it does not suppress the immune system. Instead, it:

• Binds to and activates TPO receptors in the bone marrow.
• Stimulates cell signaling pathways that promote cell growth and platelet production.

This leads to an increase in platelet counts, helping prevent excessive bleeding in ITP and supporting recovery in HS-ARS.

How is Nplate administered?

Nplate is given by subcutaneous injection once a week by a healthcare provider. This means it is injected under the skin.

This is not all the information you need to know about Nplate (romiplostim) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.