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Is it normal to have discharge on Depo shot?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on Sep 6, 2024.

Official answer

by Drugs.com

Yes, changes in vaginal discharge is a common side effect of the depo shot (also known as Depo-Provera or medroxyprogesterone injection). One way the depo shot works to prevent pregnancy is by thickening cervical mucus, which limits sperm movement in the vagina. Hormones like progestin that’s found in the depo shot can make vaginal discharge more thick and opaque. Additionally, the depo shot can cause menstrual changes that include spotting.

What is normal vaginal discharge?

Vaginal discharge is normal, on or off the depo shot, unless it occurs with certain symptoms. Most premenopausal women have about a teaspoon of vaginal discharge (fluid or mucus from the vagina) every day. Normal vaginal discharge should be white or clear, thick or have a consistency similar to mucus, and mostly odorless. Vaginal discharge also changes throughout the menstrual cycle. Keep in mind that what is normal for you may not be normal for someone else.

If you experience vaginal discharge with the following characteristics, you should be evaluated by a healthcare provider to rule out an infection or other problems:

  • Smelly discharge
  • Brown, green, or yellow discharge
  • Discharge with a cottage cheese appearance
  • Foamy discharge

Related questions

How to get rid of vaginal discharge

Vaginal discharge is mostly regulated by hormones, and is a normal protective mechanism for the vagina. If it’s bothersome, consider gently washing your vagina with water and patting dry, or wearing pantyliners during those times. Douches, feminine sprays or powders, and vaginal cleansers can cause more problems by altering the pH in the vaginal. This can raise your risk for vaginal infections.

Some causes of abnormal vaginal discharge include:

  • Vaginal yeast infection
  • Vaginal bacterial infection
  • Vaginal trichomoniasis
  • Reaction to a substance (e.g., spermicide, soap)

If you think your vaginal discharge appears or smells abnormal, contact your healthcare provider. They can do tests to make sure you do not have an infection and get you the proper treatment.

References

Chappell, C. A., et. al. 2014. The Effects of Reproductive Hormones on the Physical Properties of Cervicovaginal Fluid. In: American Journal of Obstetrics and Gynecology. DOI: https://doi.org/10.1016%2Fj.ajog.2014.03.041

Depo-Provera [package insert]. Updated July 2024. Accessed on September 9, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=199cf13e-0859-4a73-9b45-e700d0cd1049

Sobel, J. D., et. al. 2024. Patient education: Vaginal discharge in adult women (Beyond the Basics). Accessed on September 6, 2024 at https://www.uptodate.com/contents/vaginal-discharge-in-adult-women-beyond-the-basics/

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