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Invega Sustenna vs Invega Trinza vs Invega Hafyera. What's the difference?

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 25, 2024.

Official answer

by Drugs.com

The difference between Invega Sustenna, Invega Trinza, and Invega Hayfera is the length of time they last in the body. Invega Sustenna lasts for 1 month, Invega Trinza lasts for 3 months, and Invega Hayfera lasts for 6 months and only needs to be given twice a year. Before transitioning to Invega Hayfera, patients must be adequately treated with Invega Sustenna for at least 4 months, or Invega Trinza for at least one 3-month injection cycle.

Invega Sustenna, Invega Trinza, and Invega Hayfera are all made by Janssen Pharmaceuticals, and all contain the same active ingredient, paliperidone palmitate, which is an atypical antipsychotic that may be used to treat schizophrenia or schizoaffective disorder in adults. They all require administration by a healthcare professional into either the deltoid muscle of the arm or the gluteal muscle of the buttocks.

Invega Sustenna, Invega Trinza, and Invega Hayfera all utilize Alkermes' nano-particle technology. Invega Trinza has a greater concentration (312 vs 156 mg/mL of paliperidone palmitate) and a larger particle size than Invega Sustenna. Invega Hayfera has the same concentration (312 vs 312 mg/mL of paliperidone palmitate) as Invega Trinza but has been formulated to release its active ingredient over 6 months.

References
  • Invega Sustenna (paliperidone palmitate). Updated 08/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-sustenna.html
  • Learn How to Transition Adult Patients to the Longest Dosing Interval with INVEGA TRINZA®1 Invega Trinza https://www.invegatrinzahcp.com/dosing/treatment-transition
  • Invega Hafyera. (paliperidone palmitate). Updated 09/2021. Janssen Pharmaceuticals, Inc. https://www.drugs.com/pro/invega-hafyera.html#s-34069-5

Read next

Can you drink alcohol while taking Invega Sustenna?

You should avoid the use of alcohol while being treated with Invega Sustenna (paliperidone palmitate). Combining alcohol with Invega Sustenna can increase side effects like dizziness, drowsiness, and trouble concentrating. This may also affect your ability to make decisions, think clearly, or react quickly. Continue reading

How to transition to Invega Trinza from Invega Sustenna ?

Before people transition to Invega Trinza, they need to have been administered Invega Sustenna for at least 4 months and tolerated it well. For a seamless transition, it is recommended that the last two doses of Invega Sustenna are the same dosage strength before starting Invega Trinza. Start Invega Trinza up to 7 days before, on, or 7 days after the day the next 1-month Invega Sustenna dose was due. Choose a starting dose of Invega Trinza that is 3.5-fold higher than the last Invega Sustenna dose. Continue reading

How do you give an Invega Sustenna injection?

Invega Sustenna is administered by a healthcare professional into either the deltoid muscle of the arm or the gluteal muscle of the buttocks once a month following an initial loading dose period. Invega Sustenna is usually started with a dose of 234mg given IM, followed by 156mg IM one week later. Thereafter, monthly injections of 39mg to 234mg IM are given, depending on the condition being treated, individual dosage requirements, and how well the person tolerates Invega Sustenna. Continue reading

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