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How does Imvexxy work to treat dyspareunia (painful sex) due to menopause?

Medically reviewed by Drugs.com. Last updated on Aug 3, 2023.

Official answer

by Drugs.com

Imvexxy (estradiol vaginal inserts) works by adding estrogen back to the tissues in and around the vagina.

Imvexxy is a bio-identical 17β-estradiol vaginal insert for the treatment of dyspareunia (painful sexual intercourse). Dyspareunia is a result of vulvovaginal atrophy (VVA) due to lower estrogen production during menopause. VVA manifests as a thinning, drying and swelling of the vaginal walls making sexual intercourse difficult and painful.

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It takes several hours for a Vagifem insert to fully dissolve, sometimes over 24 hours, and you may find that when you insert a Vagifem the next day, the applicator comes out covered with a sticky gluey substance – this is the previous days dissolving insert which you have touched with the applicator. Continue reading

There are over 240 possible drug interactions with valerian, so a drug interaction review by your healthcare provider is important when using this herb. Use caution if combining Valerian with other substances or medicines that cause drowsiness. Continue reading

Intrarosa (prasterone) and Osphena (Ospemifene) are both used to treat dyspareunia - the medical term for difficult or painful sexual intercourse - a symptom of vulvar and vaginal atrophy, caused by menopause.

There are a number of differences between Intrarosa and Osphena, including how they are administered, what they contain, how they work and the common side effects they cause. Continue reading

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