Humira and Pregnancy: What should I know?

Limited research suggests that taking Humira may be safe during pregnancy. However, deciding whether or not to take Humira during pregnancy is a decision that should be made between you and your doctor, weighing the risks and benefits.

Does Humira Cross the Placenta?

Humira crosses the placenta, particularly in the later stages of pregnancy, exposing the baby to the medication. As a result, infants born to mothers who took Humira during pregnancy may have some level of the drug in their bloodstream. This raises concerns about potential effects on birth outcomes and infant health.

Is Humira Safe During Pregnancy?

While there has not been extensive research on pregnancy and Humira, current evidence has not established a link between in-utero exposure and significant adverse outcomes, such as major birth defects.

• The American College of Obstetricians and Gynecologists concluded that based on limited evidence, Humira and other, similar medications appear to be low-risk for use during pregnancy.
• 2020 Guidelines from the American College of Rheumatology recommend continuing Humira before and during pregnancy on a conditional basis or depending on the circumstances.

Related questions

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• What happens when you stop taking Humira?
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Risks of Untreated Inflammatory Conditions During Pregnancy

Humira is indicated for the treatment of several inflammatory conditions. These conditions can pose risks to a pregnancy when left untreated. For example, flare-ups or increased disease activity in pregnant women with rheumatoid arthritis or inflammatory bowel is associated with a higher risk of adverse pregnancy outcomes, such as preterm birth and low birth weight. Patients with these conditions who do not initiate treatment or discontinue treatment prior to or during pregnancy are more likely to have uncontrolled disease activity.

Making the Right Decision

Your doctor will help you weigh the risks of Humira exposure against the risks of uncontrolled disease during pregnancy. A personalized approach is essential to ensuring the best outcome for both mother and baby.