How does Strattera work and what's its MOA?

The mechanism of action (MOA) for Strattera (atomoxetine) in attention-deficit/hyperactivity disorder (ADHD) involves blocking the reuptake of norepinephrine in the brain. It does this by inhibiting the presynaptic norepinephrine transporter (NET), which increases the amount of norepinephrine in the synaptic cleft of neurons. Strattera also blocks the reuptake of dopamine in certain areas of the brain, like the prefrontal cortex. It belongs to the drug class called selective norepinephrine reuptake inhibitors.

Research suggests that neurochemical signaling dysregulation plays a role in ADHD. Some patients with ADHD have been shown to have lower levels of neurotransmitters like dopamine and norepinephrine. By increasing norepinephrine and dopamine in certain regions of the brain, Strattera improves ADHD symptoms like helping with attention and memory. It has also been shown to improve relationships with peers and family and help with learning.

This is not all the information you need to know about Strattera (atomoxetine) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.