How long does Vraylar stay in your system?

Vraylar can stay in your system for at least 12 weeks after stopping the medication. This means that if you and your doctor decide to stop treatment with Vraylar, you may continue to experience side effects for several weeks.

Additionally, it is recommended to avoid becoming pregnant for at least 12 weeks after stopping Vraylar, due to the risk of harm to unborn babies. If you become pregnant during treatment or within 12 weeks after stopping Vraylar, tell your doctor.

Everyone processes Vraylar differently, so the time it takes for Vraylar to leave your system can be different for you when compared to someone else.

What is the half-life of Vraylar?

A half-life is the amount of time it takes for the concentration of a substance to be lowered to 50% of the original dose in the body. Not all drugs have the same half-life. When thinking about the half-life of Vraylar, it is important to consider the half-life of three active substances that result from taking the medication.

The actions of Vraylar are thought to be due to cariprazine (the active ingredient in Vraylar) and two of its metabolites: desmethylcariprazine (DCAR) and didesmethylcariprazine (DDCAR). All three of these substances work in the body in a similar way.

The half-life of of these three active substances are as follows:

• Cariprazine: 2-4 days
• Desmethylcariprazine: 1-2 days
• Didesmethylcariprazine: 1-3 weeks