How long does it take for Ultomiris to work?

Ultomiris (ravulizumab) starts to work by the end of the first infusion. Pharmacodynamic studies show that it completely blocks the C5 complement component (a protein in the immune system) before an infusion with Ultomiris is finished. However, it can take longer for you to notice its effects. This also depends on what condition you are treating.

Myasthenia gravis

After taking Ultomiris (ravulizumab), you might notice improvements in activities of daily living within 1 week. These activities include talking, chewing, swallowing, and standing up from a chair. In clinical studies, people taking Ultomiris for generalized myasthenia gravis experienced sustained improvement through 26 weeks of treatment.

Paroxysmal nocturnal hemoglobinuria (PNH)

In a study of adults with PNH, Ultomiris reduced lactate dehydrogenase (LDH) levels within the first week after the infusion. LDH is a marker for PNH disease activity. The efficacy in children was similar to what was observed in the adult studies.

Atypical hemolytic uremic syndrome (aHUS)

In a small study of adults with aHUS who took Ultomiris, 100% of patients had complete C5 inhibition after the first infusion. By 26 weeks, 54% of adults had normal platelet count, LDH, and ≥25% improvement in serum creatinine from baseline. In children, 71% met these criteria at week 26 of treatment.

Neuromyelitis optica spectrum disorder (NMOSD)

During a clinical trial of patients taking Ultomiris for NMOSD, 100% of patients were relapse-free at week 48 and week 72, and it reduced the risk of relapse by about 99%.

Follow up with your healthcare provider about what to expect with your treatment with Ultomiris.