How long does it take for Ultomiris to work?

Ultomiris (ravulizumab) begins working by the end of the first infusion. Pharmacodynamic studies show that it fully inhibits the C5 complement component—a key immune system protein—before the infusion is completed. However, the time it takes for you to notice its effects depends on the condition being treated.

Ultomiris Effectiveness by Condition

Myasthenia gravis

After taking Ultomiris (ravulizumab), you might notice improvements in activities of daily living within 1 week. These activities include:

• Talking
• Chewing
• Swallowing
• Standing up from a chair

Clinical studies show sustained symptom relief through 26 weeks of treatment.

Paroxysmal nocturnal hemoglobinuria (PNH)

• LDH (lactate dehydrogenase) levels, a key marker of PNH disease activity, begin to decrease within the first week of treatment.
• In pediatric studies, efficacy results were similar to those observed in adults

Atypical hemolytic uremic syndrome (aHUS)

• In a small study of adults with aHUS who took Ultomiris, 100% of patients had complete C5 inhibition after the first infusion.
• By 26 weeks, 54% of adults had normal platelet count, LDH, and ≥25% improvement in serum creatinine from baseline.
• In children, 71% met these criteria at week 26 of treatment.

Neuromyelitis optica spectrum disorder (NMOSD)

• In clinical trials, 100% of patients remained relapse-free at weeks 48 and 72.
• Ultomiris reduced the risk of relapse by approximately 99%.

Your response to Ultomiris may vary based on your condition and overall health. Discuss with your doctor what to expect during treatment and any concerns you may have.