How long does it take for Provigil (modafinil) to work?

The time it takes for Provigil (modafinil) to start working is different for everyone, and can depend on your health conditions and diet. The manufacturer recommends taking it about 1 hour before the start of your work shift if you are taking it for shift work disorder. For narcolepsy and sleepiness due to obstructive sleep apnea, it is recommended to take it in the morning.

Typically, the maximum concentration of Provigil in your bloodstream is reached around 2 to 4 hours after taking a dose. Taking Provigil with food can delay the time it takes to reach maximum concentration in your bloodstream by about 1 hour. However, it is not known if food delays the time it takes for Provigil to kick in.

Talk to your healthcare provider if you are concerned about how long it is taking Provigil to work. They may be able to adjust your dose, dosing schedule, or recommend a different treatment option.

How long does Provigil last?

Provigil has a long half-life, so it only needs to be taken once a day. The wakefulness effects have been shown in studies to last the entire day after taking a dose. One study showed it continued having antifatigue effects for 11.5 hours. Still, some people may experience sleepiness in the late afternoon or evening. If this is a problem for you, talk to your healthcare provider about different dosing options.

It is estimated that Provigil lasts for about 3 days in your system after stopping the medication. However, it may take longer for it to leave your body if you have liver or kidney problems.