How long does it take for Kesimpta to work?

Kesimpta (ofatumumab) begins lowering B cells within one week of starting treatment. Clinical studies showed that:

• 77-78% of patients had B cell levels drop below the lower limit of normal within one week after the first injection.
• By two weeks, this occurred in 95-96% of patients.

How Does Kesimpta Work?

Kesimpta is a monoclonal antibody that’s injected under the skin to treat relapsing forms of multiple sclerosis. It is administered via subcutaneous injection and follows this dosing schedule:

• Once weekly for the first three weeks
• Then once monthly thereafter

Kesimpta works by reducing the number of B cells, which play a role in MS progression.

How Effective Is Kesimpta?

In clinical trials submitted for FDA approval (ASCLEPIOS I & II), Kesimpta demonstrated significant benefits over another MS treatment, Aubagio (teriflunomide).

• Lowered the annualized relapse rate more effectively than Aubagio.
• Reduced the risk of MS worsening within three months of treatment compared to Aubagio.

This FAQ does not include all the necessary information for the safe and effective use of Kesimpta (ofatumumab). Always review the full prescribing information and consult your healthcare provider with any questions.