How does Evenity work?
Evenity (romosozumab-aqqg) is a humanized monoclonal antibody that works by inhibiting the activity of sclerostin, which is a small protein found in osteocytes. It increases bone formation and reduces bone loss.
Evenity was approved in April 2019 for postmenopausal women at high risk of fracture and is given by injection by a healthcare provider once a month for a treatment period of 12 months. After the 12-month course, therapy should continue with an anti-resorptive agent.
The main side effects associated with Evenity are joint pain (arthralgia) and headache. Evenity can also increase a woman's risk of having a heart attack and stroke, and for this reason, it carries a boxed warning, and should not be given to women with other cardiovascular risk factors.
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What happens when you stop Evenity?
Within months of stopping Evenity (romosozumab), its effects on bone formation and resorption will diminish. Studies suggest that if you stop taking Evenity after three months, it can stay in the body for about 2 months. However, it can take up to 12 months for P1NP and CTX levels to return to what they were before you started treatment. Continue reading
Does Evenity cause dental problems?
Evenity (romosozumab) can rarely cause osteonecrosis of the jaw (ONJ), a rare but serious side effect. This condition occurs when there is loss of blood supply to the jaw. As a result, the jawbone is exposed and bone cells die. Continue reading
How does teriparatide (Forteo) work?
Teriparatide (Forteo), is a synthetic form of parathyroid hormone - a hormone produced naturally by the body which helps maintain blood levels of calcium within a very tight range; which in turn controls calcium levels within bone - determining how strong and dense the bones are. Continue reading
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