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What is the difference between Symjepi and EpiPen?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on March 21, 2024.

Official answer

by Drugs.com

EpiPen and Symjepi are both intramuscular or subcutaneous injections use to treat allergic emergencies (anaphylaxis), for example to bees stings or peanuts. Unlike EpiPen, Symjepi does not come as an "autoinjector" but comes only as a prefilled syringe. Symjepi has a smaller size and may be more user-friendly than other products.

Related: EpiPen and Symjepi Pricing Guide

Like EpiPen, Symjepi (epinephrine) is a single-dose, prefilled syringe of 0.3 mg or 0.15 mg epinephrine used for emergency treatment of Type 1 allergic reactions such as insect stings, food allergies (like nuts or shellfish), or medications, among other severe allergic reactions.

Symjepi and EpiPen injectors are both designed for injection through clothing, but the users of Symjepi should be in a seated position prior to injection in the outer thigh, while the EpiPen can be used while standing. Seek medical attention immediately after using Symjepi or EpiPen.

Symjepi, from Adamis, was FDA-approved in June 2017 and is sold in a 2-pack like EpiPen.

Other brands of epinephrine include Auvi-Q from Kaleo and Adrenaclick from Impax. Generic alternatives are also available on the U.S. market for emergency epinephrine delivery.

See also: Comparing EpiPen vs Symjepi

This is not all the information you need to know about Symjepi or EpiPen for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full product information here, and discuss this information and any questions you have with your doctor or other health care provider.

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How and where is an Epipen injection given?

Epipen (epinephrine injection) is given as an intramuscular (in the muscle) or subcutaneous (under the skin) injection only in the middle of the outer side of the thigh (the upper leg). It can be injected through clothing if needed. Continue reading

Is Auvi-Q the same as EpiPen?

Auvi-Q is only available as a brand-name product, while EpiPen has generic versions available. They come in different dosages and sizes. Auvi-Q has voice instructions, while EpiPen does not. Continue reading

How much does Auvi-Q cost compared to EpiPen?

The cash price for a 2-pack of Auvi-Q autoinjector is around $300 compared to $650 for an EpiPen 2-pack. Prices can vary depending upon the pharmacy you visit and if you have any coupons or manufacturer discounts. Auvi-Q and EpiPen are brand names for epinephrine autoinjectors. Continue reading

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