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Does Cytomel help with weight loss?

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 13, 2024.

Official answer

by Drugs.com

Although Cytomel does help with weight loss in people prescribed it for hypothyroidism (low thyroid levels), it is not effective at usual dosages at reducing weight in people with normal thyroid levels. Using high dosages of Cytomel to reduce weight in people with normal thyroid levels is dangerous, not safe, and can be life-threatening. Strokes, seizures, shock, coma and death have been reported in people who have taken higher than recommended dosages of Cytomel. Some symptoms of Cytomel toxicity (overdose), such as confusion, disorientation, or heart changes may not appear until several days after ingestion. Cytomel should not be used as a treatment for weight loss or obesity.

Cytomel has a narrow therapeutic index – this means there is a fine line between taking too much or having too little. Over or under treatment can be detrimental to a young person’s growth and development, cardiovascular function, bone metabolism, reproductive health, emotional state, gastrointestinal function, and glucose and lipid metabolism. In people taking Cytomel for low thyroid levels, the dosage must be carefully titrated to avoid these effects, and possible drug or food interactions taken into account.

Cytomel contains liothyronine in sodium salt form (also called LT3) which is a man-made form of a naturally occurring hormone produced by our thyroid glands called liothyronine. Cytomel may be used to increase levels of thyroid hormone in the body and treat thyroid deficiency disorders (hypothyroidism). It may also be given to help manage thyroid cancer in addition to surgery and radiotherapy, or to help diagnose conditions such as mild hyperthyroidism (high thyroid levels).

References
  • Cytomel. Updated 06/2021. Pfizer Laboratories Div Pfizer Inc https://www.drugs.com/pro/cytomel.html

Read next

Can I take Cytomel and Synthroid together?

Although the American Thyroid Association guidelines do not recommend taking Cytomel and Synthroid together, many people who are under the supervision of an internist/endocrinologist do take this combination treatment, prefer it, and have good results on it. Never take this combination without your doctor's advice because it may result in excessive levels of thyroid hormones which can be dangerous. Continue reading

How long does Cytomel take to start working?

Cytomel starts working within a few hours, but its maximum effect can take two to three days to occur. It only takes 4 hours for 95% of a dose of Cytomel to be totally absorbed. If you are taking Cytomel daily, then after a few days it will work continuously, without any drop in effect, and you should notice a reduction in your symptoms of hypothyroidism within 2 to 3 days. Continue reading

How long does Cytomel stay in your system?

Cytomel stays in your system for up to 12.5 days following the last dose. Experts calculate this period using the half-life of a drug. The half-life of Cytomel is about 2.5 days and experts agree that it takes up to 5 half-lives for a drug without active metabolites to be completely removed from the body. This calculates out to 12.5 days for Cytomel. Continue reading

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