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Is Cephalexin safe for dogs? Uses, dosage, side effects?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on Aug 9, 2024.

Official answer

by Drugs.com

Cephalexin is safe to use in dogs when under the supervision of a veterinarian. It is commonly prescribed for a variety of bacterial infections. Side effects are usually mild, and giving it with food might help prevent some stomach side effects.

What is cephalexin used for in dogs?

Cephalexin (also given under the brand names Keflex, Rilexine, and Vetolexin) is an antibiotic that may be used to treat a wide range of bacterial infections in dogs. It belongs to a group of antibiotics known as beta-lactam antibiotics and is a first-generation cephalosporin.

Some examples of infections cephalexin may be used to treat include pyoderma, urinary tract infections, and skin infections. Cephalexin is approved by the FDA for use in dogs.

How does cephalexin work in dogs?

Similar to the way it works to treat infections in humans, cephalexin interferes with the cell wall of bacteria. This causes them to die, which prevents them from multiplying and spreading.

How is cephalexin given to dogs?

Cephalexin comes as a chewable tablet, capsule, and liquid for use at home. It is usually given to you at your veterinarian’s office, but it is possible to get it elsewhere with a prescription from your vet.

You can give cephalexin to your dog with or without food. Giving the medication with food might help prevent an upset stomach.

If you were given the liquid version, use the dosing syringe provided by your veterinarian. You can give the liquid directly into your dog's mouth, or you can give it with some food. Make sure to shake the liquid well each time before giving your dog a dose.

Let your vet know if your dog is having trouble swallowing the capsules. They might be able to give you the chewable tablets or liquid instead.

How much cephalexin should I give my dog?

Your veterinarian will prescribe a dose of cephalexin that is based on your dog’s weight. Follow their instructions carefully.

  • The typical dose of cephalexin in dogs is 15 mg/kg to 45 mg/kg given by mouth every 6 to 12 hours.
  • For Rilexine chewable tablets, the recommended dose is 22 mg/kg (10 mg/lb) given by mouth twice a day for 28 days when treating pyoderma.

Your veterinarian might prescribe a different dose that works best for your dog.

How soon does cephalexin work in dogs?

Cephalexin starts to work within 2 hours, but it might take a few days for your dog to feel better. Make sure to give your dog the entire amount of cephalexin prescribed by your veterinarian. Stopping treatment too soon can cause your dog's infection to come back or be harder to treat.

The amount of time your dog will need to take cephalexin depends on their infection and how quickly they respond to treatment.

What are the side effects of cephalexin in dogs?

Most side effects from cephalexin are mild. Common side effects your dog may experience include nausea, vomiting, and diarrhea. They might also have less energy or a poor appetite.

A more serious but rare side effect is an allergic reaction. If you notice your dog having trouble breathing, pale gums, or a skin rash, contact your vet right away.

Dogs with kidney problems are at a higher risk of experiencing side effects, and they should be monitored closely.

Does cephalexin interact with any other medications?

There are no known drug interactions with cephalexin in dogs. Still, it may interact with certain medications such as probenecid and warfarin. Tell your vet about all of the medications your dog is taking, including vitamins and supplements. They can help you screen for any possible drug interactions with cephalexin.

What if I miss a dose of cephalexin for my dog?

If you forget to give your dog a dose, give it to them as soon as you remember. However, if it is close to the time for your dog’s next dose, just skip the missed dose and continue with your normal dosing schedule. Never double-up or give your dog extra doses of cephalexin because this can lead to more side effects.

References

Gollakner R. Cephalexin. VCA Animal Hospitals. Accessed on August 9, 2024 at https://vcahospitals.com/know-your-pet/cephalexin

Mercer, M. A., et. al. 2022. Cephalosporins and Cephamycins Use in Animals. Merck Manual Veterinary Manual: Professional Version. Accessed on August 9, 2024 at https://www.merckvetmanual.com/pharmacology/antibacterial-agents/cephalosporins-and-cephamycins-use-in-animals

Plumb’s Veterinary Medication Guides. (2020). Cephalexin. Accessed on August 9, 2024 at https://www.seattle.gov/documents/Departments/AnimalShelter/Cephalexin%20Info%20Sheet.pdf

Rilexine chewable tablets [package insert]. Updated July 2018. Virbac. Accessed on August 9, 2024 at https://us.virbac.com/home/our-product/pagecontent/product-selector/rilexine-cephalexin-chewable.html

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