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Does Bactrim make you tired?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on Oct 17, 2024.

Official answer

by Drugs.com

Yes, Bactrim (sulfamethoxazole and trimethoprim) can make you tired. Fatigue, or feeling tired, is a side effect listed in the Bactrim prescribing information. Some people reported feeling tired while taking it during clinical trials.

Bactrim is an antibiotic that may be used to treat a variety of infections, such as urinary tract infections, ear infections, and travelers’ diarrhea. It comes as a tablet that is taken by mouth.

The incidence of tiredness from taking Bactrim is not known. There are other reasons you may feel more tired while taking Bactrim, including:

  • An underlying infection is causing you to feel more tired than usual.
  • Bactrim can cause your skin to be more sensitive to sunlight. This means you may get sunburned more easily. Having a sunburn can also make you feel more tired.
  • During an infection, you may be at a higher risk of dehydration. Being dehydrated can also cause fatigue.

If you are feeling very tired and it is affecting your ability to do your normal daily activities, let your healthcare provider know. They can help you determine the cause.

Related questions

How to manage fatigue while taking Bactrim

There are a few things you can try to help boost your energy while taking antibiotics like Bactrim. Some examples include:

  • Get plenty of rest to help your body recover from the infection
  • Take breaks throughout the day
  • Plan most of your activities in the morning when you have more energy
  • Eat a well balanced diet and avoid processed foods
  • Drink plenty of fluids to stay hydrated

This is not all the information you need to know about Bactrim (sulfamethoxazole and trimethoprim) for safe and effective use and does not take the place of your healthcare provider’s directions. Review the full patient medication guide and discuss this information and any questions you have with your doctor or other health care provider.

References

Bactrim DS [package insert]. Updated July 2024. Sun Pharmaceutical Industries, Inc. Accessed 10/17/24 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f59d0c04-9c66-4d53-a0e1-cb55570deb62

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