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Does acamprosate cause weight gain?

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 17, 2024.

Official answer

by Drugs.com

Weight gain is frequently reported as a side effect of acamprosate by people taking this medication to control alcohol cravings associated with alcohol use disorder. Acamprosate can also cause weight loss, but this is reported infrequently.

Weight gain and weight loss are more commonly reported by patients who take both acamprosate and antidepressant medications at the same time.

Weight gain linked to acamprosate is thought to be caused by the increase in appetite that some people taking this medication experience. It is not clear whether increased appetite is caused by the medication itself or from stopping drinking alcohol.

Acamprosate is also known by the name Campral, which is a discontinued brand name of the drug. Various generic versions of acamprosate are currently available.

References

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Acamprosate vs naltrexone: How do they compare?

Acamprosate and naltrexone are two different medications that are used in the treatment of alcohol use disorder. They work in different ways to help people who are dependent on alcohol to abstain from drinking it. Naltrexone is also used for the treatment of opioid use disorder.

Acamprosate was thought to be slightly more effective at helping people with alcohol use disorder remain off alcohol, while naltrexone was thought to be slightly more effective at helping reduce heavy drinking and cravings, according to the results of a meta-analysis which used data from 64 trials.

Results from two small studies, however, indicate that naltrexone is more effective than acamprosate in a number of areas. Continue reading

Does acamprosate make you sick if you drink alcohol?

Acamprosate does not make you feel sick if you drink alcohol, unlike some other medications used in the treatment of alcohol use disorder (alcoholism). Continue reading

How long does it take for acamprosate to work?

Acamprosate usually takes several days to a week to start working fully. About five days after you start taking this medication, you’ll reach a point where the amount of acamprosate in your system will remain at a consistent level if you continue to take it as prescribed. Continue reading

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