Tacrolimus (International)

In the US, Tacrolimus (tacrolimus systemic) is a member of the drug class calcineurin inhibitors and is used to treat Crohn's Disease, Graft Versus Host Disease, Nephrotic Syndrome, Organ Transplant - Rejection Prophylaxis and Organ Transplant - Rejection Reversal.

US matches:

• Tacrolimus oral and injection
• Tacrolimus topical
• Tacrolimus (Intravenous)
• Tacrolimus (Oral)
• Tacrolimus (Topical)
• Tacrolimus
• Tacrolimus 0.03% Ointment
• Tacrolimus 0.1% Ointment
• Tacrolimus Capsules
• Tacrolimus Extended-Release Capsules
• Tacrolimus Extended-Release Tablets
• Tacrolimus Granules for Suspension
• Tacrolimus Injection
• Tacrolimus ER Capsules
• Tacrolimus Ointment

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

D11AH01,L04AA05,L04AD02

CAS registry number (Chemical Abstracts Service)

0104987-11-3

Chemical Formula

C44-H69-N-O12

Molecular Weight

804

Therapeutic Category

Immunosuppressant

Chemical Name

Immunosuppreβant derived from Streptomyces tsukubaensis

Foreign Names

• Tacrolimusum (Latin)
• Tacrolimus (German)
• Tacrolimus (French)
• Tacrolimus (Spanish)

Generic Names

• Tacrolimus (OS: USAN, BAN)
• Tacrolimus (PH: USP 41)
• Tacrolimus Hydrate (OS: JAN)
• FK 506 (Fujisawa) (IS)
• FR 900506 (IS)
• L 683590 (IS)
• Tacrolimus Hydrate (PH: JP XVII)
• Tacrolimus Monohydrate (PH: BP 2018, Ph. Eur. 9.3)

Brand Names

• Adoport
  Lek, Slovenia
• Adoport 0,5 mg
  Sandoz, Turkey
• Adoport 1 mg
  Sandoz, Turkey
• Adoport 5 mg
  Sandoz, Turkey
• Advagraf
  Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Estonia; Astellas, Georgia; Astellas, Hong Kong; Astellas, Croatia (Hrvatska); Astellas, Iceland; Astellas, Italy; Astellas, Latvia; Astellas, Norway; Astellas, Philippines; Astellas, Portugal; Astellas, Romania; Astellas, Russian Federation; Astellas, Slovakia; Astellas, Taiwan; Astellas, South Africa; Astellas Pharma, Poland; Astellas Pharma, Serbia; Astellas Pharma China, China; Astellas Pharma Europe, Netherlands; Astellas Pharma Europe BV, Greece; DKSH, Malaysia
• Advagraf 0,5 mg
  Astellas, Turkey
• Advagraf 0,5 mg retard
  Astellas, Hungary
• Advagraf 0.5mg
  Astellas, Switzerland
• Advagraf 1 mg
  Astellas, Turkey
• Advagraf 1 mg retard
  Astellas, Hungary
• Advagraf 1mg
  Astellas, Switzerland
• Advagraf 3 mg retard
  Astellas, Hungary
• Advagraf 3mg
  Astellas, Switzerland
• Advagraf 5 mg
  Astellas, Turkey
• Advagraf 5 mg retard
  Astellas, Hungary; Astellas Pharma, Germany
• Advagraf 5mg
  Astellas, Switzerland
• Advagraf LP
  Hikma, Tunisia
• Advagraf PR
  Astellas Pharma, Cyprus
• Advagraf Prolonged Release
  Astellas, Slovenia
• Advagraf XL
  Astellas Pharma, Australia
• Astagraf XL
  Astellas, United States
• Atolimus
  Beximco, Bangladesh
• Cellmune 0.1%
  Industrial Farmaceutica Cantabria, United Kingdom
• Cidimus
  Novartis, Chile; Sandoz, Poland
• Cromus
  Procaps, Colombia
• Cromus Ung
  Unimed, Peru
• Dermitopic 0.1%
  Pharmaswiss Ceska Republika, United Kingdom
• Effac
  Meider, Taiwan
• Envarsus
  Chiesi, Greece; Chiesi, Lithuania; Chiesi Farmaceutici, Slovenia; Chiesi Pharmaceuticals, Bosnia & Herzegowina; Chiesi Pharmaceuticals, Poland; Providens, Croatia (Hrvatska)
• Envarsus 0.75 mg retard
  Chiesi, Hungary
• Envarsus 1 mg retard
  Chiesi, Hungary
• Envarsus LP
  Chiesi, France
• Envarsus XR
  Veloxis Pharmaceuticals, United States
• Gecrol
  Heaton, Czech Republic; Heaton, Slovakia
• Imugraft 0.5
  Ambica, Philippines
• Lecron
  PharOS, Italy
• Limus
  Alco, Bangladesh
• Modigraf
  Astellas, Lithuania; Astellas, Slovenia; Astellas, Slovakia; Astellas Pharma, Germany; Astellas Pharma, Denmark; Astellas Pharma Europe, Iceland; Orifarm, Norway
• Modigraf 0.2 mg
  Astellas, Switzerland; Astellas, Hungary
• Modigraf 1 mg
  Astellas, Hungary
• Modigraf 1mg
  Astellas, Switzerland
• Mustopic
  Systopic, India
• Norgraf
  Nordic, Peru
• Oligma
  Eczacibasi Ilac Pazarlama, Turkey
• Pacrolim
  Alphapharm, Australia
• Panolimus
  Biem, Turkey
• Proalid
  Italmex, Mexico
• Prodermic
  Iqfarma, Peru
• Produke
  Titan, Georgia
• Produke SR
  Titan, Georgia
• Prograf
  Astellas, Bosnia & Herzegowina; Astellas, Canada; Astellas, Czech Republic; Astellas, Egypt; Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Indonesia; Astellas, Israel; Astellas, Italy; Astellas, South Korea; Astellas, Macedonia; Astellas, Malta; Astellas, Philippines; Astellas, Portugal; Astellas, Sweden; Astellas, Slovakia; Astellas, Thailand; Astellas, Turkey; Astellas, Taiwan; Astellas, United States; Astellas, South Africa; Astellas Pahrmaceuticals Aebe, Cyprus; Astellas Pharma, Australia; Astellas Pharma, Denmark; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma, Singapore; Astellas Pharma a/s, Iceland; Astellas Pharma China, China; Astellas Pharma Europe, Romania; Astellas Pharma Singapore, Vietnam; DKSH, Malaysia; Farmagon, Norway; Gador, Argentina; Gador, Chile; Gador, Paraguay; Hikma, Kuwait; Hikma, Lebanon; Hikma, Oman; Hikma, Tunisia; Janssen, Venezuela; Janssen-Cilag, Brazil; Orifarm, Norway
• Prograf 0.5 mg
  Astellas, Hungary
• Prograf 0.5mg
  Astellas, Switzerland; Astellas, Israel; Gador, Uruguay
• Prograf 1 mg
  Astellas, Hungary
• Prograf 1mg
  APS, Switzerland; Astellas, Switzerland; Astellas, Israel
• Prograf 5 mg
  Astellas, Hungary
• Prograf 5 mg/ml
  Astellas, Hungary
• Prograf 5mg
  Astellas, Switzerland; Astellas, Israel; Gador, Uruguay
• Prograf 5mg/ml
  Astellas, Switzerland; Astellas Pharma, Austria; Astellas Pharma, Germany
• Prograf XL
  Astellas Pharma, Australia; Gador, Argentina; Gador, Chile
• Protopic
  Astellas, Georgia; Astellas, Greece; Astellas, Hong Kong; Astellas, Italy; Astellas, Portugal; Astellas, Taiwan; Astellas Ireland, Serbia; Astellas Pharma China, China; Janssen, Malaysia; Janssen, Philippines; Janssen, Singapore; Janssen-Cilag/Astellas, Indonesia; LEO, Norway; LEO Pharma, Canada; LEO Pharma, Greece; LEO Pharma, Lithuania; LEO Pharma, Latvia; LEO Pharma, Turkey; LEO Pharma, United States; Leofarma, Brazil; Roche Uruguay, Uruguay
• Protopic 0.01%
  Astellas, Croatia (Hrvatska)
• Protopic 0.03%
  Astellas, Switzerland; Astellas, Croatia (Hrvatska); Astellas, Israel; Astellas Pharma, Cyprus; Astellas Pharma, Poland; LEO Pharma, Spain; LEO Pharma, Netherlands
• Protopic 0.1%
  Astellas, Israel; Astellas Pharma, Cyprus; LEO Pharma, Switzerland; LEO Pharma, Netherlands; Leo Pharma A/S, Iceland
• Protopy
  Astellas, Lithuania
• Regraf
  MMC, Georgia
• Remus
  Square, Bangladesh
• Rocimus
  Mega Lifesciences, Philippines
• Seegraf
  Micro Labs, India
• Tacloran
  Wockhardt, India
• Tacni
  Pliva, Bosnia & Herzegowina; Pliva, Croatia (Hrvatska); Teva, Czech Republic; Teva, Spain; Teva, Greece; Teva, Lithuania; Teva, Norway; Teva Pharma, Cyprus; Teva Pharma, Slovenia; Teva Pharmaceuticals, Poland
• Tacni 0.5mg
  ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
• Tacni 1mg
  ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
• Tacni 5mg
  ratiopharm Arzneimittel, Austria; Teva, Germany; Teva, Hungary; Teva, Luxembourg; Teva Pharma, Switzerland
• Tacpan 0,5mg
  Panacea Biotec Germany, Germany
• Tacpan 1mg
  Panacea Biotec Germany, Germany
• Tacpan 5mg
  Panacea Biotec Germany, Germany
• Tacroderm
  AHPL, India
• Tacrograf
  Biocon, India
• Tacrol
  Acme, Bangladesh
• Tacroli
  Hwang's, Taiwan
• Tacrolim
  Incepta, Bangladesh
• Tacrolimus
  Accord Healthcare, United States; Belcher Pharmaceuticals, United States; Dr. Reddy's, United States; Fougera, United States; Hospira, United States; Lek, Bosnia & Herzegowina; Mylan, United States; Panacea Biotec, United States; Sandoz, United States; Strides Pharma, United States
• Tacrolimus Accord
  Accord, Lithuania; Accord Healthcare, Poland
• Tacrolimus Accord 0.1%
  Accord Healthcare, United Kingdom
• Tacrolimus Accord Healthcare
  Accord Healthcare, Italy
• Tacrolimus Cinfa
  Cinfa, Spain
• Tacrolimus Medis
  Medis, Tunisia
• Tacrolimus Mylan
  Mylan, Spain
• Tacrolimus Pharma Arte
  Pharma Arte, Paraguay
• Tacrolimus PharmaSwiss
  PharmaSwiss, Estonia; PharmaSwiss, Lithuania
• Tacrolimus Pierre Fabre 0.1%
  Pierre Fabre, United Kingdom
• Tacrolimus Sandoz
  Novartis, New Zealand; Sandoz, Hong Kong
• Tacrolimus Servimedic
  Servimedic, Uruguay
• Tacrolimus Stada
  STADA, Spain
• Tacrolimus Teva 0.1%
  Teva Pharmaceuticals, United Kingdom
• Tacrolin
  Farma-Tek, Turkey
• Tacromus
  Zydus Cadila, India
• Tacrotec
  Marzan Pharma, Philippines
• Tacrotopic
  Lafedar, Argentina
• Tacroz
  Glenmark, Ecuador; Glenmark, India; Glenmark Pharmaceuticals, Vietnam
• Tacroz Forte
  Glenmark, Ecuador; Glenmark, India; Glenmark, Peru; Glenmark Pharmaceuticals, Vietnam
• Tagraf
  Panacea Biotech, Philippines
• Takrocept
  Intas, Poland
• Takrolimus Belupo
  Belupo, Croatia (Hrvatska)
• Takrolimus Genera
  Genera, Croatia (Hrvatska)
• Takrolimus Sandoz
  Lek, Serbia
• Taliximun
  PharmaSwiss, Poland
• Tames
  Olcare Laboratories, India
• Tarfic
  Libbs, Brazil
• Tarolimus 0.03%
  Andalous, Egypt
• Tartrime
  Gobbi-Novag, Argentina; Juste, Spain
• T-Inmun
  Complex Therapeutics, Chile; Mediderm, Chile; Recalcine, Ecuador; Recalcine, Paraguay
• Topgraf
  GlaxoSmithKline, India
• Topiclin
  Solebio, Turkey
• Tracsus
  Alvogen, Croatia (Hrvatska); Alvogen Luxembourg, Romania; Cinfa, Macedonia; Laboratorios Cinfa, Bosnia & Herzegowina
• Traderma
  Serral, Mexico
• T-Top
  Wallace, India
• T-Top Forte
  Wallace, India
• Vingraf
  Emcure Pharma, Philippines
• Adoport
  Sandoz, Belgium; Sandoz, Portugal; Sandoz España, Spain
• Adoport 0,5 mg
  Sandoz, France; Sandoz, United Kingdom
• Adoport 0.75 mg
  Sandoz, United Kingdom
• Adoport 1 mg
  Sandoz, France; Sandoz, United Kingdom
• Adoport 2 mg
  Sandoz, France; Sandoz, United Kingdom
• Adoport 5 mg
  Sandoz, France; Sandoz, United Kingdom
• Adport
  Sandoz, Denmark; Sandoz, Georgia; Sandoz, Netherlands; Sandoz, Sweden
• Adport 0,5 mg
  Sandoz, Austria
• Adport 1 mg
  Sandoz, Austria
• Adport 2 mg
  Sandoz, Austria
• Adport 5 mg
  Sandoz, Austria
• Advagraf
  Astellas, Czech Republic; Astellas, Spain; Astellas, Finland; Astellas, Ireland; Astellas, South Korea; Astellas, Lithuania; Astellas, Sweden; Astellas, Thailand; Astellas Pharma, Belgium; Astellas Pharma, Denmark; Astellas Pharma, Singapore; Astellas Pharma Singapore, Vietnam
• Advagraf 0,5 mg
  Astellas, France
• Advagraf 0,5 mg retard
  Abacus, Austria; Astellas Pharma, Germany; Astellas Pharma Europe, Austria; Haemato Pharm, Austria
• Advagraf 0.5mg
  Astellas, Israel
• Advagraf 0.5mg prolonged-release
  Astellas Pharma, United Kingdom
• Advagraf 1 mg
  Astellas, France
• Advagraf 1 mg prolonged-release
  Astellas Pharma, United Kingdom
• Advagraf 1 mg retard
  Astellas Pharma, Germany; Astellas Pharma Europe, Austria
• Advagraf 3 mg prolonged-release
  Astellas Pharma, United Kingdom
• Advagraf 3 mg retard
  Astellas Pharma, Germany
• Advagraf 3mg
  Astellas, France
• Advagraf 5 mg
  Astellas, France
• Advagraf 5 mg prolonged-release
  Astellas Pharma, United Kingdom
• Advagraf 5 mg retard
  Abacus, Austria; Astellas Pharma Europe, Austria; Emra-Med Arzneimittel, Austria
• Advagraf-0.5
  Astellas, Luxembourg
• Advagraf-1
  Astellas, Luxembourg
• Advagraf-3
  Astellas, Luxembourg
• Advagraf-5
  Astellas, Luxembourg
• Crilomus
  Hexal, Germany
• Crilomus 0.5mg
  Sandoz, Switzerland
• Crilomus 0.75mg
  Sandoz, Switzerland
• Crilomus 1mg
  Sandoz, Switzerland
• Crilomus 2mg
  Sandoz, Switzerland
• Crilomus 5mg
  Sandoz, Switzerland
• Dermitopic 0.1%
  PharmaSwiss, Poland
• Envarsus
  Chiesi, Czech Republic; Chiesi, Germany; Chiesi, Denmark; Chiesi, Estonia; Chiesi, Spain; Chiesi, United Kingdom; Chiesi, Ireland; Chiesi, Norway; Chiesi, Sweden; Chiesi Farmaceutici, Netherlands; Chiesi Pharma, Finland
• Envarsus 0.75mg
  Chiesi, Switzerland; Chiesi Farmaceutici, Austria
• Envarsus 1mg
  Chiesi, Switzerland; Chiesi Farmaceutici, Austria
• Envarsus 4mg
  Chiesi, Switzerland; Chiesi Farmaceutici, Austria
• Framebin
  Pisa, Mexico
• Graceptor
  Astellas, Japan
• Limustin
  Landsteiner, Mexico
• Modigraf
  Astellas, Czech Republic; Astellas, Estonia; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Ireland; Astellas, Latvia; Astellas, Norway; Astellas, Sweden; Astellas Pharma, United Kingdom; Astellas Pharma, Poland; Astellas Pharma Europe, Netherlands
• Modigraf 0,2mg
  Astellas Pharma Europe, Austria
• Modigraf 1mg
  Astellas Pharma Europe, Austria
• Octralin
  Raam, Mexico
• Pharmacor Tacrolimus
  Pharmacor, Australia
• Prograf
  Astellas, Bulgaria; Astellas, Spain; Astellas, Finland; Astellas, France; Astellas, Croatia (Hrvatska); Astellas, Ireland; Astellas, Japan; Astellas, South Korea; Astellas, Malta; Astellas, Norway; Astellas, Sweden; Astellas Ireland, Serbia; Astellas Pharma, United Kingdom; Janssen-Cilag, Mexico
• Prograf 0,5mg
  Astellas Pharma, Austria; Astellas Pharma, Germany
• Prograf 1mg
  Astellas Pharma, Austria; Astellas Pharma, Germany
• Prograf 5mg
  Astellas Pharma, Austria; Astellas Pharma, Germany
• Prograf XL
  Janssen-Cilag, Mexico
• Prograft
  Astellas, Belgium; Astellas Pharma Europe, Netherlands; BModesto, Netherlands; Delphi, Netherlands; Dr. Fisher Farma, Netherlands; EU-Pharma, Netherlands; Euro Registratie, Netherlands; Medcor Pharmaceuticals, Netherlands
• Prograft-0.5
  Astellas, Luxembourg
• Prograft-1
  Astellas, Luxembourg
• Prograft-5
  Astellas, Luxembourg
• Protopic
  Astellas, South Korea; Astellas, South Africa; Hikma, Oman; Janssen, Thailand; LEO, Ireland; LEO Pharma, Czech Republic; LEO Pharma, Denmark; LEO Pharma, Estonia; LEO Pharma, Finland; LEO Pharma, Sweden; Productos Roche, Chile; Roche, Ecuador; Roche, Mexico
• Protopic 0.03%
  Astellas, Japan; Astellas, Slovakia; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, Belgium; Leo Pharma, Finland; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania
• Protopic 0.1%
  Astellas, Japan; Astellas, Slovakia; Astellas Pharma, Poland; Eurim-Pharm, Austria; LEO, Germany; LEO Laboratories, United Kingdom; Leo Pharma, Austria; Leo Pharma, France; Leo Pharma, Hungary; Leo Pharma, Luxembourg; Leo Pharma, Romania
• Sandoz Tacrolimus
  Sandoz, Canada
• Tacforius
  Teva Nederland, Netherlands
• Tacni
  Pharmachemie, Netherlands; Teva, Sweden
• Tacrobell
  Chong Kun Dang, South Korea
• Tacrocel
  Sandoz, Croatia (Hrvatska)
• Tacrocel 0.5mg
  LEK Pharmaceuticals, Israel
• Tacrocel 1mg
  LEK Pharmaceuticals, Israel
• Tacrocel 5mg
  LEK Pharmaceuticals, Israel
• Tacrocin
  Intas, Philippines
• Tacroderm
  Lazar, Argentina
• Tacrolimus
  Ayumi Pharmaceutical, Japan; Mylan Seiyaku, Japan; Nichi-Iko Pharmaceutical, Japan; Nihon Generic, Japan; Nipro, Japan; Sandoz, Argentina; Sandoz, Georgia; Towa Yakuhin, Japan; Nipro Pharma Nipurofama, Japan
• Tacrolimus 0.1%
  Iwaki Seiyaku, Japan; Pola Pharma, Japan; Takata Pharmaceutical, Japan; Nipro Pharma Nipurofama, Japan
• Tacrolimus Accord
  Accord Healthcare, Netherlands; Lyomark Pharma, Germany
• Tacrolimus AL
  Aliud Pharma, Germany
• Tacrolimus Apotex
  Pharmacor, Australia
• Tacrolimus CF
  Centrafarm, Netherlands
• Tacrolimus Heumann
  Heumann, Germany
• Tacrolimus HEXAL
  Hexal, Germany
• Tacrolimus Lek
  LEK farmacevtska, Macedonia
• Tacrolimus Pergamus
  Accord Healthcare, Bulgaria; Actavis, Bulgaria
• Tacrolimus Sandoz
  Sandoz, Australia; Sandoz, Netherlands; Sandoz, Romania; STADA, Spain
• Takrozem
  Pierre Fabre, Netherlands
• Talymus 0.1%
  Senju Seiyaku, Japan
• Tarimus
  Hanmi, South Korea

Glossary

Further information on drug naming conventions: International Nonproprietary Names.

Further information

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