Copovidone
Medically reviewed by Drugs.com. Last updated on Oct 18, 2023.
Excipient (pharmacologically inactive substance)
What is it?
Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Copovidone has better plasticity than povidone as a tablet binder, is less hygroscopic, more elastic, and better for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent and binder. It is widely used in the food, cosmetic and pharmaceutical industry.[1]
Copovidone is generally regarded as nontoxic. However, oral consumption of excessive quantities may produce stomach upset. It has not been shown to be sensitizing to the skin. Animal studies in rats and dogs do not show significant toxicity with high dietary levels.[1]
The average molecular weight of copovidone is usually expressed as a K-value and it ranges between 45 and 70.[2]
List of medications using Copovidone
- Atorvastatin Calcium 10 mg
- Bupropion Hydrochloride Extended-Release (SR) 100 mg
- Bupropion Hydrochloride Extended-Release (SR) 150 mg
- Bupropion Hydrochloride Extended-Release (SR) 150 mg
- Bupropion Hydrochloride Extended-Release (XL) 150 mg
- Bupropion Hydrochloride Extended-Release (XL) 300 mg
- Bupropion Hydrochloride Extended-Release (XL) 300 mg
- Chest Congestion Relief DM dextromethorphan hydrobromide 20mg / guaifenesin 400mg
- Gabapentin 600 mg
- Gabapentin 600 mg
- Gabapentin 600 mg
- Gabapentin 600 mg
- Gabapentin 800 mg
- Gabapentin 800 mg
- Gabapentin 800 mg
- Gabapentin 800 mg
- Gabapentin 800 mg
- Gabapentin 600 mg
- Gabapentin 600 mg
- Guaifenesin 400 mg
References
- Medicines Complete. Pharmaceutical Excipients. Monographs. Copovidone. Accessed April 8, 2012. http://www.medicinescomplete.com
- Mellert W et al. Carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. Food Chem Toxicol 2004; 42(10): 1573–1587.
Further information
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