Vonjo and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Vonjo (pacritinib).
Caffeine Pacritinib
Moderate Drug Interaction
Pacritinib may increase the blood levels and effects of caffeine. This may increase the risk and/or severity of side effects of caffeine. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Pacritinib Food
Major Food Interaction
Grapefruit juice may increase the blood levels of pacritinib. This can increase the risk of side effects such as diarrhea, low blood platelet count, infection, and an irregular heart rhythm that may be serious or life-threatening. You should avoid consuming grapefruit and grapefruit juice during treatment with pacritinib. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if you have any questions or concerns or if you develop dizziness, lightheadedness, fainting, shortness of breath, chest pain, or heart palpitations during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Vonjo drug interactions
There are 727 drug interactions with Vonjo (pacritinib).
Vonjo disease interactions
There are 7 disease interactions with Vonjo (pacritinib) which include:
- cardiovascular risk
- malignancy
- thrombosis
- Pacritinib-diarrhea
- Pacritinib-infection
- Pacritinib-hemorrhage
- Pacritinib-QT prolongation
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
