E S P and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with E S P (erythromycin / sulfisoxazole).
Erythromycin Alcohol (Ethanol)
Minor Drug Interaction
Information for this minor interaction is available on the professional version.
Erythromycin Food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Food may variably affect the bioavailability of different oral formulations and salt forms of erythromycin. The individual product package labeling should be consulted regarding the appropriate time of administration in relation to food ingestion. Grapefruit juice may increase the plasma concentrations of orally administered erythromycin. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. In an open-label, crossover study consisting of six healthy subjects, the coadministration with double-strength grapefruit juice increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of a single dose of erythromycin (400 mg) by 52% and 49%, respectively, compared to water. The half-life was not affected. The clinical significance of this potential interaction is unknown.
MANAGEMENT: In general, optimal serum levels are achieved when erythromycin is taken in the fasting state, one-half to two hours before meals. However, some erythromycin products may be taken without regard to meals.
E S P drug interactions
There are 707 drug interactions with E S P (erythromycin / sulfisoxazole).
E S P disease interactions
There are 13 disease interactions with E S P (erythromycin / sulfisoxazole) which include:
- colitis
- liver disease
- prematurity
- hematologic toxicity
- hypersensitivity reactions
- liver disease
- porphyria
- renal dysfunction
- myasthenia gravis
- QT prolongation
- crystalluria
- hemodialysis
- urinary obstruction
More about E S P (erythromycin / sulfisoxazole)
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- Drug class: miscellaneous antibiotics
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.