Alteplase Injection Shortage
Last Updated: April 22, 2025
Status: Current
Products Affected - Description
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- Activase intravenous lyophilized powder for injection, Genentech, 100 mg, kit, 1 count, NDC 50242-0065-27
Reason for the Shortage
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- Genentech did not provide a reason for the shortage of Activase 100 mg kits. The 50 mg kits are available.
Available Products
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- Activase intravenous lyophilized powder for injection, Genentech, 50 mg, kit, 1 count, NDC 50242-0044-13
Estimated Resupply Dates
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- Genentech has Activase 100 mg kits on back order and the company cannot estimate a release date.
Alternative Agents & Management
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- Genentech has issued a Dear Healthcare Provider letter which provides instructions on how to prepare a dose over 50 mg using Activase 50 mg vials. The Dear Healthcare Provider letter can be found at https://www.gene.com/download/pdf/Activase_DHCP_Important-Prescribing-Information_11-14-24.pdf. The full instructions for alternate dose preparation can be found at :https://www.gene.com/download/pdf/activase_instructions_for_alternate_preparation.pdf.
Updated
Updated April 22, 2025 by Leslie Jensen, PharmD, Drug Information Specialist. Created November 22, 2024 by Leslie Jensen, PharmD, Drug Information Specialist. © 2025, Drug Information Service, University of Utah, Salt Lake City, UT.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.