Drug Interactions between Vitamin D2 and Vitamin D3

Using ergocalciferol together with cholecalciferol should generally be avoided unless otherwise directed by your doctor. Both of these medications are forms of vitamin D, and taking too much vitamin D can lead to toxic effects related to excessive calcium levels in the blood and urine, such as irregular heart rhythm, seizures, kidney stones, and eventual calcification of blood vessels, cornea, and soft tissues of the body. If you take digoxin, a common heart medication, having a high blood level of calcium can also increase the risk of developing digoxin toxicity. Talk to your doctor if you have any questions or concerns. You will need close monitoring of your calcium and phosphorus levels to safely use these medications. You should avoid an abrupt increase in your dietary calcium intake, and seek medical attention if you experience early symptoms of vitamin D intoxication such as weakness, fatigue, headache, drowsiness, vertigo, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, metallic taste, muscle pain, bone pain, muscle incoordination, and low muscle tone. Late symptoms may include frequent urination, excessive thirst, weight loss, conjunctivitis ("pink eye"), light sensitivity, runny nose, itching, increased body temperature, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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