Co-trimoxazole Interactions
There are 450 drugs known to interact with Co-trimoxazole (sulfamethoxazole/trimethoprim), along with 12 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 63 are major, 175 are moderate, and 212 are minor.
- View all 450 medications that may interact with Co-trimoxazole
- View Co-trimoxazole alcohol/food interactions (1)
- View Co-trimoxazole disease interactions (12)
Most frequently checked interactions
View interaction reports for Co-trimoxazole (sulfamethoxazole / trimethoprim) and the medicines listed below.
- acyclovir
- allopurinol
- amlodipine
- amoxicillin
- aspirin
- atorvastatin
- azithromycin
- bisoprolol
- ceftriaxone
- cefuroxime
- cephalexin
- ciprofloxacin
- clarithromycin
- cyclophosphamide
- dexamethasone
- doxycycline
- fluconazole
- folic acid
- furosemide
- ibuprofen
- losartan
- metronidazole
- omeprazole
- ondansetron
- Paracetamol (acetaminophen)
- prednisolone
- prednisone
- tacrolimus
- tramadol
- Vitamin D3 (cholecalciferol)
Co-trimoxazole alcohol/food interactions
There is 1 alcohol/food interaction with Co-trimoxazole (sulfamethoxazole / trimethoprim).
Co-trimoxazole disease interactions
There are 12 disease interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim) which include:
- colitis
- hematologic toxicity
- hypersensitivity reactions
- liver disease
- porphyria
- renal dysfunction
- folate deficiency
- crystalluria
- hemodialysis
- urinary obstruction
- dialysis
- renal dysfunction
Report options
More about Co-trimoxazole (sulfamethoxazole / trimethoprim)
- Co-trimoxazole consumer information
- Compare alternatives
- Reviews (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: sulfonamides
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.