Xyrem Interactions
There are 346 drugs known to interact with Xyrem (sodium oxybate), along with 6 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 244 are major, and 102 are moderate.
- View all 346 medications that may interact with Xyrem
- View Xyrem alcohol/food interactions (3)
- View Xyrem disease interactions (6)
Most frequently checked interactions
View interaction reports for Xyrem (sodium oxybate) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- baclofen
- bupropion
- clonazepam
- cyclobenzaprine
- Cymbalta (duloxetine)
- gabapentin
- ibuprofen
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- melatonin
- metformin
- methylphenidate
- modafinil
- Nuvigil (armodafinil)
- omeprazole
- propranolol
- Provigil (modafinil)
- Ritalin (methylphenidate)
- Singulair (montelukast)
- tramadol
- trazodone
- venlafaxine
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vyvanse (lisdexamfetamine)
- Wellbutrin XL (bupropion)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Xyrem alcohol/food interactions
There are 3 alcohol/food interactions with Xyrem (sodium oxybate).
Xyrem disease interactions
There are 6 disease interactions with Xyrem (sodium oxybate) which include:
- depression
- hx drug/alcohol abuse
- glaucoma
- liver disease
- sensitivity to salt intake
- sleep apnea/respiratory depression
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More about Xyrem (sodium oxybate)
- Xyrem consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (108)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
