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Drug Interactions between pirtobrutinib and ubrogepant

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

ubrogepant pirtobrutinib

Applies to: ubrogepant and pirtobrutinib

Pirtobrutinib can increase the blood levels of ubrogepant. This may increase side effects such as nausea and sleepiness. The usual recommended dose for migraine is 50 mg in individuals who are receiving treatment with pirtobrutinib. A second dose, if needed, may be taken 2 hours after the initial dose. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a different dose to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

pirtobrutinib food

Applies to: pirtobrutinib

Consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit should be avoided during treatment with pirtobrutinib as they may increase the blood levels of pirtobrutinib. This may increase the risk of side effects such as infection, bruising, bleeding, fatigue, muscle pain, diarrhea, swelling, and difficulty breathing. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

ubrogepant food

Applies to: ubrogepant

Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase side effects such as nausea and sleepiness. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe an alternative that does not interact, or you may need a different dose to safely use your medication with grapefruit and grapefruit juice. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer