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Drug Interactions between Paxlovid and Tri-Sprintec

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ethinyl estradiol ritonavir

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate) and Paxlovid (nirmatrelvir / ritonavir)

Ritonavir may reduce the blood levels and effects of ethinyl estradiol. If you are using birth control pills or another hormone-type contraceptive such as a patch, shot, vaginal ring or implant, you should talk to your doctor before taking ritonavir. You may need an alternative or additional method of birth control during and for at least two weeks after treatment with ritonavir in order to avoid an unintended pregnancy. Let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of ethinyl estradiol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major

norgestimate ritonavir

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate) and Paxlovid (nirmatrelvir / ritonavir)

Ritonavir may reduce the blood levels and effects of norgestimate. If you are using birth control pills or another hormone-type contraceptive such as a patch, shot, vaginal ring or implant, you should talk to your doctor before taking ritonavir. You may need an alternative or additional method of birth control during and for at least two weeks after treatment with ritonavir in order to avoid an unintended pregnancy. Let your doctor know if you experience bleeding outside of your menstrual cycle, since it may indicate reduced effectiveness of norgestimate. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

norgestimate food

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)

Grapefruit juice may increase the blood levels of certain medications such as norgestimate. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with norgestimate. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Moderate

ritonavir food

Applies to: Paxlovid (nirmatrelvir / ritonavir)

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

Moderate

ethinyl estradiol food

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.

MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.

Minor

ethinyl estradiol food

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: Tri-Sprintec (ethinyl estradiol / norgestimate)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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