Afrin Original Interactions
There are 51 drugs known to interact with Afrin Original (oxymetazoline nasal), along with 3 disease interactions. Of the total drug interactions, 6 are major, and 45 are moderate.
- View all 51 medications that may interact with Afrin Original
- View Afrin Original disease interactions (3)
Most frequently checked interactions
View interaction reports for Afrin Original (oxymetazoline nasal) and the medicines listed below.
- acetaminophen
- albuterol
- Allegra (fexofenadine)
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- benzonatate
- CoQ10 (ubiquinone)
- cyclobenzaprine
- doxycycline
- famotidine
- Flonase (fluticasone nasal)
- fluticasone nasal
- gabapentin
- ibuprofen
- levothyroxine
- lisinopril
- magnesium oxide
- melatonin
- metformin
- MiraLAX (polyethylene glycol 3350)
- Mucinex (guaifenesin)
- omeprazole
- ondansetron
- prednisone
- tramadol
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
Afrin Original disease interactions
There are 3 disease interactions with Afrin Original (oxymetazoline nasal) which include:
Report options
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More about Afrin Original (oxymetazoline nasal)
- Afrin Original consumer information
- Compare alternatives
- Reviews (5)
- Side effects
- Dosage information
- During pregnancy
- Drug class: nasal antihistamines and decongestants
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.