Prilosec OTC Interactions
There are 240 drugs known to interact with Prilosec OTC (omeprazole), along with 3 disease interactions. Of the total drug interactions, 25 are major, 167 are moderate, and 48 are minor.
- View all 240 medications that may interact with Prilosec OTC
- View Prilosec OTC disease interactions (3)
Most frequently checked interactions
View interaction reports for Prilosec OTC (omeprazole) and the medicines listed below.
- albuterol
- amlodipine
- aspirin
- Aspirin Low Strength (aspirin)
- atorvastatin
- Benadryl (diphenhydramine)
- Cymbalta (duloxetine)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- gabapentin
- hydrochlorothiazide
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- melatonin
- metformin
- metoprolol
- multivitamin
- prednisone
- simvastatin
- Singulair (montelukast)
- Synthroid (levothyroxine)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Prilosec OTC disease interactions
There are 3 disease interactions with Prilosec OTC (omeprazole) which include:
Report options
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More about Prilosec OTC (omeprazole)
- Prilosec OTC consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (21)
- Side effects
- Dosage information
- During pregnancy
- Drug class: proton pump inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.