Aleve Interactions
There are 451 drugs known to interact with Aleve (naproxen), along with 11 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 99 are major, 335 are moderate, and 17 are minor.
- View all 451 medications that may interact with Aleve
- View Aleve alcohol/food interactions (3)
- View Aleve disease interactions (11)
Most frequently checked interactions
View interaction reports for Aleve (naproxen) and the medicines listed below.
- acetaminophen
- Advil (ibuprofen)
- albuterol
- amlodipine
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- cyclobenzaprine
- Fish Oil (omega-3 polyunsaturated fatty acids)
- gabapentin
- hydrochlorothiazide
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- magnesium oxide
- melatonin
- meloxicam
- metformin
- multivitamin
- omeprazole
- pantoprazole
- prednisone
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
Aleve alcohol/food interactions
There are 3 alcohol/food interactions with Aleve (naproxen).
Aleve disease interactions
There are 11 disease interactions with Aleve (naproxen) which include:
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- sodium
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
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More about Aleve (naproxen)
- Aleve consumer information
- Compare alternatives
- Reviews (154)
- Drug images
- Latest FDA alerts (8)
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: Nonsteroidal anti-inflammatory drugs
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
