Drug Interactions between medroxyprogesterone and olaparib

Consumer information for this interaction is not currently available.

ADDITIONAL CONTRACEPTION RECOMMENDED: In vitro data suggest a theoretical potential for olaparib to decrease the plasma concentrations of hormonal contraceptives. Olaparib has been shown in vitro to induce several CYP450 isoenzymes, which may cause increased metabolism of contraceptive hormones. However, olaparib also inhibits CYP450 3A4 in vitro and is predicted to be a mild in vivo inhibitor of CYP450 3A4, the isoenzyme that is primarily responsible for the metabolic clearance of contraceptive hormones. Clinical data regarding this interaction and its potential impact on the efficacy of hormonal contraceptives are currently lacking.

MANAGEMENT: Until more information is available, some authorities recommend that an additional non-hormonal contraceptive method be considered during treatment with olaparib. For women with hormone-dependent cancer, two non-hormonal contraceptive methods should be considered. Findings in animal reproductive studies as well as its mechanism of action suggest olaparib may have teratogenic and genotoxic potential and could cause embryofoetal harm when administered to a pregnant woman, thus it is particularly important that female patients not become pregnant during treatment. All women of childbearing potential must use reliable contraception before starting olaparib, during treatment, and for 6 months after receiving the last dose of olaparib, unless abstinence is the chosen method of contraception. Two highly effective and complementary forms of contraception are typically recommended. A pregnancy test should be performed on all women of childbearing potential prior to treatment, at regular intervals during treatment, and six months after receiving the last dose. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed. Intrauterine systems are unlikely to be significantly affected because of their local action.