Skip to main content

Drug Interactions between ketoconazole and primidone

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Major

ketoconazole primidone

Applies to: ketoconazole and primidone

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the oral bioavailability and plasma concentrations of itraconazole and ketoconazole. In vitro studies have shown that CYP450 3A4 is the major enzyme involved in their metabolism, and pharmacokinetic studies as well as case reports have demonstrated decreases in itraconazole and ketoconazole systemic exposure (AUC) by at least 80% and sometimes even to undetectable levels when coadministered with potent CYP450 3A4 inducers such as rifampin or phenytoin, including reports of treatment failure.

MANAGEMENT: Concomitant use of itraconazole or ketoconazole with potent CYP450 3A4 inducers should generally be avoided. Some authorities recommend avoiding coadministration of potent CYP450 3A4 inducers from 2 weeks before and during treatment with these azole antifungal agents unless the benefits outweigh the risk of potentially reduced antifungal efficacy. If coadministration is required, clinical response and antifungal activity should be closely monitored and the itraconazole or ketoconazole dosage increased as necessary.

Drug and food interactions

Major

primidone food

Applies to: primidone

Ask your doctor before using primidone together with ethanol, this can add to dizziness, drowsiness and other side effects of primidone. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with primidone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

ketoconazole food

Applies to: ketoconazole

You should avoid the use of alcohol while being treated with ketoconazole. Ketoconazole may cause liver damage and using it with alcohol or products containing alcohol may increase that risk. In addition, consumption of alcoholic beverages or products containing alcohol during treatment with ketoconazole may trigger a disulfiram-like reaction in some patients, with unpleasant symptoms such as flushing, palpitations, and nausea. Ketoconazole may be taken with or without food. You should avoid consumption of grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with ketoconazole unless directed otherwise by your doctor. Grapefruit juice may increase the blood levels of ketoconazole. This may increase the risk and/or severity of side effects and liver problems. You should seek immediate medical attention if you develop signs and symptoms of liver damage during treatment with ketoconazole, such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer