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Drug Interactions between ethinyl estradiol and minocycline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

minocycline ethinyl estradiol

Applies to: minocycline and ethinyl estradiol

Antibiotics such as minocycline may reduce the effects of ethinyl estradiol in some women. If you are using ethinyl estradiol for birth control, you may be at increased risk for pregnancy or breakthrough bleeding. Be sure to alert your doctor if you are having any vomiting and/or diarrhea as this too can impact how well ethinyl estradiol works. Talk to your doctor or pharmacist to determine if you should use an alternative or additional form of birth control during or after treatment with minocycline. In addition, some birth control preparations may include "placebo" non-hormonal pills that contain iron. If you are taking these iron-containing pills during treatment with minocycline, you should separate the dosing times by several hours so that the iron does not interfere with absorption of the antibiotic. Ask your doctor or pharmacist for information on when best to take these medications. If you are using ethinyl estradiol for a purpose other than birth control, please let your doctor know if you have any questions or notice any changes in how well ethinyl estradiol is working. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Moderate

minocycline food

Applies to: minocycline

Iron can bind to minocycline in the gastrointestinal tract, which may prevent their absorption into the bloodstream and possibly reduce their effectiveness. To avoid or minimize the interaction, iron-containing medications and minocycline should preferably be taken at least three to four hours apart in most cases. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

ethinyl estradiol food

Applies to: ethinyl estradiol

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of ethinyl estradiol may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In a study of 30 healthy volunteers administered the CYP450 1A2 substrate tizanidine, the systemic exposure (AUC) of tizanidine was 3.9 times greater in women using an oral contraceptive containing ethinyl estradiol.

MANAGEMENT: Patients should be monitored for increased adverse effects of the CYP450 1A2 substrate during concomitant use with ethinyl estradiol. Product labeling for the specific CYP450 1A2 substrate should be consulted for additional recommendations.

Minor

ethinyl estradiol food

Applies to: ethinyl estradiol

Information for this minor interaction is available on the professional version.

Minor

ethinyl estradiol food

Applies to: ethinyl estradiol

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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