Motrin PM Interactions
There are 745 drugs known to interact with Motrin PM (diphenhydramine/ibuprofen), along with 21 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 111 are major, 622 are moderate, and 12 are minor.
- View all 745 medications that may interact with Motrin PM
- View Motrin PM alcohol/food interactions (3)
- View Motrin PM disease interactions (21)
Most frequently checked interactions
View interaction reports for Motrin PM (diphenhydramine / ibuprofen) and the medicines listed below.
- Advil (ibuprofen)
- albuterol
- alprazolam
- Ambien (zolpidem)
- amitriptyline
- aspirin
- Benadryl (diphenhydramine)
- ciprofloxacin
- clonazepam
- cyclobenzaprine
- doxycycline
- gabapentin
- hydrochlorothiazide
- hydroxyzine
- ibuprofen
- lisinopril
- losartan
- melatonin
- metformin
- metoprolol
- Mucinex (guaifenesin)
- omeprazole
- pantoprazole
- prednisone
- sertraline
- tramadol
- Tylenol (acetaminophen)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
Motrin PM alcohol/food interactions
There are 3 alcohol/food interactions with Motrin PM (diphenhydramine / ibuprofen).
Motrin PM disease interactions
There are 21 disease interactions with Motrin PM (diphenhydramine / ibuprofen) which include:
- depression
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- PKU
- anemia
- heart failure
- hepatotoxicity
- hyperkalemia
- hypertension
- platelet aggregation inhibition
More about Motrin PM (diphenhydramine / ibuprofen)
- Motrin PM consumer information
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.