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Drug Interactions between clonidine / epinephrine / ketorolac / ropivacaine and Flomax

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

EPINEPHrine tamsulosin

Applies to: clonidine / epinephrine / ketorolac / ropivacaine and Flomax (tamsulosin)

Consumer information for this interaction is not currently available.

MONITOR: Theoretically, the pharmacologic effects of agents that act through agonism at the alpha receptor may be antagonized by those that act via antagonism at the same receptor, and vice versa. Alpha-1 agonists and alpha agonists with beta-agonist effects exert opposing effects on vascular tone and blood pressure than alpha-1 antagonists. Some of these agents act on both alpha-1 and alpha-2 receptors, though they may have a stronger affinity for one or the other. The severity of the interaction may also be influenced by the degree of systemic absorption of each agent.

MANAGEMENT: Monitoring for diminished effects on blood pressure and vasoconstriction is recommended if an alpha-agonist (e.g., epinephrine, norepinephrine, ephedrine, metaraminol) is coadministered with an alpha-antagonist (e.g., phentolamine, phenoxybenzamine, terazosin). If the concomitant alpha agonist being used also acts on beta receptors, the effects of unopposed beta stimulation should also be considered.

References

  1. (2002) "Product Information. Intropin (dopamine)." DuPont Pharmaceuticals
  2. (2022) "Product Information. EPHEDrine Sulfate (ePHEDrine)." Akorn Inc
  3. (2016) "Product Information. Akovaz (ephedrine)." Eclat Pharmaceuticals
  4. (2016) "Product Information. Adrenaclick Two-Pack (epinephrine)." Amedra Pharmaceuticals LLC
  5. (2016) "Product Information. Auvi-Q (epinephrine)." sanofi-aventis
  6. (2016) "Product Information. EpiPen (epinephrine)." Dey Laboratories
  7. (2016) "Product Information. Adrenalin (epinephrine)." A-S Medication Solutions
  8. (2016) "Product Information. Epinephrine (epinephrine)." Physicians Total Care
  9. (2022) "Product Information. Anapen (adrenaline (epinephrine))." Link Medical Products Pty Ltd T/A Link Pharmaceuticals, 2.4
  10. (2023) "Product Information. Epinephrine (EPINEPHrine)." International Medication Systems, Limited
  11. (2023) "Product Information. Epinephrine (EPINEPHrine)." BPI Labs LLC, SUPPL-10
View all 11 references

Drug and food interactions

Moderate

tamsulosin food

Applies to: Flomax (tamsulosin)

Food may affect the intestinal absorption of tamsulosin. You should take tamsulosin approximately one-half hour following the same meal each day to ensure steady absorption and blood levels of the drug.

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Moderate

cloNIDine food

Applies to: clonidine / epinephrine / ketorolac / ropivacaine

CloNIDine and ethanol may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

ketorolac food

Applies to: clonidine / epinephrine / ketorolac / ropivacaine

Ask your doctor before using ketorolac together with ethanol. Do not drink alcohol while taking ketorolac. Alcohol can increase your risk of stomach bleeding caused by ketorolac. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

EPINEPHrine food

Applies to: clonidine / epinephrine / ketorolac / ropivacaine

Both EPINEPHrine and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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