Drug Interactions between anti-inhibitor coagulant complex and emicizumab

Using anti-inhibitor coagulant complex together with emicizumab may increase the risk of blood clots, which can lead to serious complications such as stroke, pulmonary embolism (blockage of pulmonary artery), heart attack, heart failure, collapse, and kidney failure. In addition, there have been reports of a rare but serious condition called thrombotic microangiopathy (TMA) that results in blood clots forming in small vessels such as those found in the brain and kidneys. Manifestations of TMA include low platelet count, low red blood cell count (anemia), bleeding, bruising, drowsiness, confusion, seizures, and kidney failure. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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