Drug Interactions between Akynzeo for Injection and lorlatinib

Fosnetupitant may increase the blood levels of lorlatinib in some patients. This may increase the risk of serious side effects such as seizures, hallucinations, cognitive problems (e.G., confusion, forgetfulness, difficulty concentrating), mood disorders (e.G., depression), sleep impairment, increases in cholesterol and triglycerides, slow or abnormal heartbeats, and inflammation of the lungs. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should contact your doctor if you experience dizziness, lightheadedness, abnormal heartbeats, or any new or worsening lung problems such as difficulty breathing, shortness of breath, cough, or fever. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.