Drug Interactions between AK-Tob and netilmicin

Both tobramycin ophthalmic and netilmicin belong to the same class of antibiotics known as aminoglycosides. Since the medication in tobramycin ophthalmic may be absorbed in the bloodstream after application to the eye, combining it with netilmicin may increase the risk of serious side effects reported with aminoglycosides. Patients who may be particularly susceptible include the very young, elderly, and those who are dehydrated or have preexisting kidney disease. Be sure to use tobramycin ophthalmic as described in the product labeling. Proper administration technique, such as closing your eye and occluding your tear duct after administration, has been shown to help reduce the amount of medicine available to be absorbed into your bloodstream. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know immediately if you experience hearing loss, ringing in the ears, vertigo, and/or any symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.