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Tylenol with Codeine #4 Interactions

There are 579 drugs known to interact with Tylenol with Codeine #4 (acetaminophen/codeine), along with 19 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 132 are major, 434 are moderate, and 13 are minor.

Does Tylenol with Codeine #4 interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Most frequently checked interactions

View interaction reports for Tylenol with Codeine #4 (acetaminophen / codeine) and the medicines listed below.

Tylenol with Codeine #4 alcohol/food interactions

There is 1 alcohol/food interaction with Tylenol with Codeine #4 (acetaminophen / codeine).

Tylenol with Codeine #4 disease interactions

There are 19 disease interactions with Tylenol with Codeine #4 (acetaminophen / codeine) which include:


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.