Angiotensin II inhibitors with thiazides

Angiotensin II inhibitors with thiazides is a combination medicine containing both an angiotensin II inhibitor and a thiazide. The angiotensin II inhibitor stops the activation of the angiotensin II receptor which results in vasodilatation, a reduction of aldosterone production and reduced vasopressin. These effects cause the reduction of blood pressure. Thiazide diuretics decrease active re-absorption of sodium and chloride ions by inhibiting the sodium/chloride co-transporter in the distal convoluted tubule. This causes an increase in urine production (diuresis) and results in a decrease in blood volume and a reduction in blood pressure.