Xcopri Dosage

Generic name: CENOBAMATE 12.5mg; CENOBAMATE 25mg
Dosage form: tablets
Drug class: Carbamate anticonvulsants

Medically reviewed by Drugs.com. Last updated on Aug 27, 2024.

General Dosing Recommendations

Monotherapy and Adjunctive Therapy

XCOPRI is administered orally once daily with or without food. The recommended dosage and titration, which should not be exceeded because of the potential for serious adverse reactions, is included in Table 1.

Table 1: Recommended Dosage for Partial-Onset Seizures in Adults
Initial Dosage
Week 1 and 2	12.5 mg once daily
Titration Regimen
Week 3 and 4	25 mg once daily
Week 5 and 6	50 mg once daily
Week 7 and 8	100 mg once daily
Week 9 and 10	150 mg once daily
Maintenance Dosage
Week 11 and thereafter	200 mg once daily
Maximum Dosage
If needed based on clinical response and tolerability, dose may be increased above 200 mg by increments of 50 mg once daily every two weeks to 400 mg.	400 mg once daily

Dosage Modifications in Patients with Hepatic Impairment

For patients with mild to moderate (Child-Pugh Class A to B) hepatic impairment, the maximum recommended dosage is 200 mg once daily. XCOPRI is not recommended for use in patients with severe (Child-Pugh Class C) hepatic impairment.

2.3 Administration Instructions

XCOPRI can be taken whole or the tablets can be crushed. The crushed tablet can be mixed with water and either administered by mouth as an oral suspension or administered via a nasogastric tube, as described below.

Administration of Crushed Tablets by Mouth as Oral Suspension

Crush the appropriate number of tablet(s) for the prescribed dose.
In a cup, combine the crushed tablet(s) and 25 mL of water.
Swirl to suspend the crushed tablet(s).
Drink the suspension immediately. Do not store the tablet-water mixture for later use.
To ensure no tablet residue is left in the container, rinse the container with 25 mL of water and drink.
Visually confirm that no particles are left in the container. If particles remain, repeat step 5.

Administration of Crushed Tablets via Nasogastric (NG) Tube

Crush the appropriate number of tablet(s) for the prescribed dose.
In an appropriate container, combine the crushed tablet(s) and 25 mL of water.
Swirl to suspend the crushed tablet(s).
Ensuring no particles are left in the container, instill the suspension with a syringe into the NG tube.
Refill the catheter-tip syringe again with 10 mL of water, swirl gently, and administer.
Visually confirm that no particles are left in the syringe. If particles remain, repeat step 5.

2.4 Discontinuation of XCOPRI

If XCOPRI is discontinued, the dosage should be gradually reduced over a period of at least 2 weeks, unless safety concerns require abrupt withdrawal.