Vytorin Dosage

Generic name: EZETIMIBE 10mg, SIMVASTATIN 10mg
Dosage form: tablet
Drug class: Antihyperlipidemic combinations

Medically reviewed by Drugs.com. Last updated on Nov 20, 2024.

Important Dosage and Administration Information

Take VYTORIN orally once daily in the evening with or without food.
The maximum recommended dosage is VYTORIN 10/40 mg once daily. The VYTORIN 10/80 mg daily dosage is restricted to adult patients who have been taking VYTORIN 10/80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity.
For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving VYTORIN 10/40 mg daily, prescribe alternative LDL-C-lowering treatment.
If as dose is missed, take the missed dose as soon as possible. Do not double the next dose.
Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating VYTORIN, and adjust the dosage if necessary.

Recommended Dosage in Adult Patients

The recommended dosage range of VYTORIN 10/10 mg to 10/40 mg once a day.

Recommended Dosage in Pediatric Patients 10 Years of Age and Older with HeFH

The recommended dosage range of VYTORIN 10/10 mg to 10/40 mg once a day.

Recommended Dosage in Patients with Renal Impairment

Renal impairment is a risk factor for statin-associated myopathy. Doses of VYTORIN exceeding 10/20 mg should be used with caution and close monitoring in patients with moderate to severe renal impairment.

There are no dosage adjustment recommendations for patients with mild renal impairment.

Dosage Modifications Due to Drug Interactions

Concomitant use of VYTORIN with the following drugs requires dosage modification of VYTORIN.

Patients taking Lomitapide
Reduce the dosage of VYTORIN by 50%. Do not exceed VYTORIN 10/20 mg once daily (or 10/40 mg once daily for patients who have previously taken VYTORIN 10/80 mg daily chronically while taking lomitapide).

Patients taking Verapamil, Diltiazem, or Dronedarone
Do not exceed VYTORIN 10/10 mg once daily.

Patients taking Amiodarone, Amlodipine, or Ranolazine
Do not exceed VYTORIN 10/20 mg once daily.

Patients taking Bile Acid Sequestrants
In patients taking a bile acid sequestrant, administer VYTORIN at least 2 hours before or 4 hours after the bile acid sequestrant.