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Ponesimod Dosage

Medically reviewed by Drugs.com. Last updated on Jul 4, 2024.

Applies to the following strengths: 20 mg

Usual Adult Dose for Multiple Sclerosis

Treatment Initiation:
2 mg orally once a day on Day 1 and 2
3 mg orally once a day on Day 3 and 4
4 mg orally once a day on Day 5 and 6
5 mg orally once a day on Day 7
6 mg orally once a day on Day 8
7 mg orally once a day on Day 9
8 mg orally once a day on Day 10
9 mg orally once a day on Day 11
10 mg orally once a day on Days 12, 13, and 14

Maintenance Dose:
20 mg orally once a day starting on Day 15

Use: For the treatment of adult patients with relapsing forms of multiple sclerosis (MS), to
include clinically isolated syndrome, relapsing-remitting disease, and active secondary
progressive disease

Comments:

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Dose Adjustments

Reinitiating Therapy After Treatment Interruption:
If fewer than 4 consecutive doses are missed:


If 4 or more consecutive doses are missed during titration or maintenance:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug has a high plasma protein binding (greater than 99%); therefore, dialysis is not expected to alter the total and unbound drug concentration, and no dose adjustments are anticipated based on these considerations.

Other Comments

Administration advice:


Storage requirements:

Monitoring:
PRIOR TO TREATMENT INITIATION:

AFTER TREATMENT INITIATION:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.