Opsynvi Dosage
Generic name: MACITENTAN 10mg, TADALAFIL 40mg
Dosage form: tablet, film coated
Drug class: Agents for pulmonary hypertension
Medically reviewed by Drugs.com. Last updated on Apr 2, 2024.
Recommended Dosage
OPSYNVI is taken orally once daily with or without food. Swallow the tablets whole, with water. Do not cut, crush, or chew tablets. If the patient misses a dose of OPSYNVI, tell the patient to take it as soon as possible and then take the next dose at the regularly scheduled time. Tell the patient not to take two doses at the same time if a dose has been missed.
For patients who are treatment-naïve to any PAH specific therapy or transitioning from ERA monotherapy
The recommended starting dose of OPSYNVI is one 10 mg/20 mg tablet taken orally once daily with or without food for one week. If tolerated, up titrate OPSYNVI to one 10 mg/40 mg tablet taken orally once daily with or without food as the maintenance dose.
Pregnancy Testing in Females of Reproductive Potential
Obtain a pregnancy test in females of reproductive potential prior to OPSYNVI treatment, monthly during treatment and one month after stopping OPSYNVI. Initiate treatment with OPSYNVI in females of reproductive potential only after a negative pregnancy test [see Contraindications (4.1), Warnings and Precautions (5.1), and Use in Specific Populations (8.3)].
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