Nabilone Dosage

Usual Adult Dose for Nausea/Vomiting - Chemotherapy Induced

Recommended Dose:

• 1 mg or 2 mg orally 2 times a day

Initial Dose:

• The dose should be given 1 to 3 hours before the first dose of the chemotherapeutic agent is administered.
• The lower starting dose should be used to minimize side effects; the dose can be increased as necessary.

Maintenance Dose:

• This drug may be given 2 or 3 times a day during the entire course of each cycle of chemotherapy and, if needed, for 48 hours after the last dose of each cycle.

Maximum Dose:

• 2 mg orally 3 times a day

Comments:

• A dose of 1 mg or 2 mg orally the night before each cycle of chemotherapy may be useful.
• This drug is not intended to be used on an as-needed basis or as a first-line antiemetic.

Use: Treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

If Disturbing Psychiatric Symptoms Occur:

• Withhold subsequent doses until patient has returned to baseline mental status, then resume routine dosing (with a lower initiating dose) if clinically indicated.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule II

Dialysis

Data not available

Other Comments

General:

• Prescriptions for this drug should be limited to the amount necessary for a single cycle of chemotherapy (i.e., a few days).
• Cross-tolerance between this drug and delta-9-THC (marijuana) has been demonstrated in animal studies.
• Overdosage: Activated charcoal is often more effective than emesis or lavage in decreasing absorption of drugs from the GI tract; consider charcoal instead of or in addition to gastric emptying and protect the patient's airway during this process. General supportive care and monitoring of vital signs is also recommended. The use of forced diuresis, peritoneal dialysis, hemodialysis, charcoal hemoperfusion, and cholestyramine has not been reported.
• The estimated oral median lethal dose in female mice: between 1,000 to 2,000 mg/kg; in the female rat: greater than 2,000 mg/kg.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer