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Loncastuximab Tesirine Dosage

Medically reviewed by Drugs.com. Last updated on Jun 5, 2024.

Applies to the following strengths: lpyl 10 mg

Usual Adult Dose for Lymphoma

0.15 mg/kg IV over 30 minutes on Day 1 of each cycle (every 3 weeks) for 2 cycles, then 0.075 mg/kg IV over 30 minutes every 3 weeks for subsequent cycles

Comments:


Use: For the treatment of adult patients with relapsed or refractory large B-cell lymphoma after 2 or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, and high-grade B-cell lymphoma

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild hepatic impairment (total bilirubin upper limit of normal [ULN] or less and aspartate aminotransferase (AST) greater than ULN or total bilirubin greater than 1 to 1.5 x ULN and any AST): No adjustment recommended; monitor patients for increased adverse reactions and modify the dose if needed.
Moderate or severe hepatic impairment (total bilirubin greater than 1.5 x ULN and any AST): Data not available

Dose Adjustments

DOSE DELAYS OR MODIFICATIONS:
HEMATOLOGIC ADVERSE REACTIONS:

NONHEMATOLOGIC ADVERSE REACTIONS:
Edema or Effusion:
Other Adverse Reactions:

If dosing is delayed by more than 3 weeks due to toxicity related to this drug, reduce subsequent doses by 50%; if toxicity reoccurs following dose reduction, consider discontinuation.
NOTE: If toxicity requires dose reduction following the second dose of 0.15 mg/kg (Cycle 2), the patient should receive the dose of 0.075 mg/kg for Cycle 3.

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:


Reconstitution/preparation techniques:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.