Likmez Dosage

Recommended Dosage for Trichomoniasis

Adult Female and Male Patients:

• One-day Treatment–Administer 2 g (20 mL) of LIKMEZ, either as a single oral dose or in 2 divided oral doses of 1 g (10 mL) each, given on the same day.
• Seven-day Course of Treatment−Administer 250 mg (2.5 mL) of LIKMEZ orally 3 times daily for 7 consecutive days.

The dosage regimen should be individualized. Single-dose treatment may help improve compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen.

A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. There are some data from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen. Further, some patients may tolerate one treatment regimen better than the other.

When repeat courses of LIKMEZ are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Recommended Dosage for Amebiasis

Adult Patients:

• For acute intestinal amebiasis (acute amebic dysentery):Administer 750 mg (7.5 mL) of LIKMEZ orally three times daily for 5 days to 10 days.
• For amebic liver abscess:Administer 500 mg (5 mL) or 750 mg (7.5 mL) of LIKMEZ orally three times daily for 5 days to 10 days.

Pediatric Patients:

• Administer 35 mg/kg/24 hours to 50 mg/kg/24 hours of LIKMEZ, divided into three doses, to a maximum dose of 2,250 mg/24 hours (maximum dose 750 mg/dose or 7.5 mL/dose), orally for 10 days.

Recommended Dosage for Anaerobic Bacterial Infections

In the treatment of most serious anaerobic infections, intravenous metronidazole is usually administered initially.

Adult Patients: Administer 7.5 mg/kg of LIKMEZ orally every six hours (approx. 500 mg (5 mL) for a 70 kg adult) for 7 days to 10 days. Infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Do notexceed a maximum of 4 g (40 mL) during a 24-hour period.

Recommended Dosage in Patients with Severe Hepatic Impairment

For patients with severe hepatic impairment (Child-Pugh C), reduce the dose of LIKMEZ by 50%.

Recommended Dosage in Patients Undergoing Hemodialysis

Hemodialysis removes significant amounts of metronidazole and its metabolites from systemic circulation. The clearance of metronidazole will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of LIKMEZ cannot be separated from the hemodialysis session, consider a supplemental dose of LIKMEZ following the hemodialysis session, depending on the patient’s clinical situation .

No adjustment in LIKMEZ dose is needed in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) .

Important Administration Instructions

Shake the bottle well before administering the recommended dosage.

Use a calibrated oral dosing device to correctly measure the prescribed dose of medication. Do not use household teaspoons or tablespoons to measure doses. Calibrated oral dosing devices may be obtained from the pharmacy.