Lentocilin Dosage

Lentocilin S suspension for injection is to be EXCLUSIVELY administered by DEEP INTRAMUSCULAR (IM) INJECTION. Deep IM administration of this medicine requires a rigorous technique and should be performed only by experienced health technicians and in places prepared for the emergency treatment of a possible anaphylactic reaction.

Posology
Adults
Group A streptococcal infections - Upper respiratory tract infections:
1,200,000 IUunits in a single dose.
Primary, secondary and early latent syphilis: 2,400,000 unitsIU in a single dose (injection at two different sites).
Late latent syphilis or of unknown duration: 2,400,000 unitsIU (injection at two different sites) weekly for 3 consecutive weeks.
Tertiary syphilis: 2,400,000 unitsIU (injection at two different sites) weekly for 3 consecutive weeks.
Yaws, bejel and pinta: 1,200,000 unitsIU in a single dose.

Prophylaxis of rheumatic fever: 1,200,000 unitsIU every 4 weeks. In high-risk patients it is recommended administration of 3 inevery 3 weeks.

Prevention of diphtheria, including elimination of the asymptomatic carrier state: 1,200,000 unitsIU in a single dose.

Newborns aged ≥ 1 month
Asymptomatic congenital syphilis: 50,000 unitsIU/kg in a single dose (maximum dose: 2,400,000 unitsIU/dose).
Benzathine benzylpenicillin is not recommended in newborns with proven or highly probable congenital syphilis.

Children
Group A Streptococcal infections - Upper respiratory tract infections:
25,000 - 50,000 unitsIU/kg in a single dose (maximum dose: 1,200,000 IUunits/dose) or
weight < 27 kg: 300,000-600,000 IU units in a single dose
weight ≥ 27 kg: 1,200,000 unitsIU in a single dose.

- Primary, secondary and early latent syphilis: 50,000 unitsIU/kg (maximum dose: 2,400,000 unitsIU/dose) in a single dose.
- Late latent syphilis or latent syphilis of unknown duration: 50,000 unitsIU/kg (maximum dose: 2,400,000 unitsIU/dose) weekly for 3 weeks.

- Yaws, bejel and pinta: 300,000 unitsIU as a single dose in children aged less than 6 years or 1,200,000 IUunits in a single dose in children aged 6 years and older.

-Prophylaxis of rheumatic fever: 25,000 - 50,000 unitsIU/kg in a single dose (maximum dose: 1,200,000 unitsIU/dose) or
weight < 27 kg: 300,000 - 600,000 unitsIU in a single dose
weight ≥ 27 kg: 1,200,000 unitsIU in a single dose.

Prevention of diphtheria (including elimination of the asymptomatic carrier state):
- children aged < 6 years (or weight < 30 kg): 600,000 unitsIU in a single dose
- children aged ≥ 6 years (or weight ≥ 30 kg): 1,200,000 unitsIU in a single dose.

Special populations

Elderly - Dose adjustment is not necessary. However, since the elderly have a higher likelihood of decreased renal function, this must be taken into consideration during the selection of the posology and may be useful to monitor renal function.

Renal insufficiency - Toxic concentrations of benzylpenicillin following administration of the usually recommended dose are not expected.

Liver insufficiency - Dose adjustment is not necessary.